Cloned (Comment) | Organism |
---|---|
expression in GALE-null line of Chineses hamster ovary cells. GALE-null cells accumulats abnormally high levels of Hal-1-P and UDP-Gal and abnormally low levels of UDP-Glc and UDP-GLcNAc in the presence of galactose. Human GALE expression corrects each of theses defects | Homo sapiens |
expression in GALE-null line of Chinesese hamster ovary cells. Enzyme from Escherichia coli can not restore the metabolic balance, because unlike the mammalian enzyme it can not catalyze the interconversion of UDP-GalNAc and UDP-GlcNAc | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose | Escherichia coli | enzyme catalyzes the first step of the Lelpoir pathway | UDP-glucose | - |
r | |
UDP-galactose | Homo sapiens | enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules | UDP-glucose | - |
r | |
UDP-GalNAc | Homo sapiens | enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules | UDP-GlcNAc | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no interconversion of UDP-GalNAc and UDP-GlcNAc | Escherichia coli | ? | - |
? | |
UDP-galactose | - |
Escherichia coli | UDP-glucose | - |
r | |
UDP-galactose | - |
Homo sapiens | UDP-glucose | - |
r | |
UDP-galactose | enzyme catalyzes the first step of the Lelpoir pathway | Escherichia coli | UDP-glucose | - |
r | |
UDP-galactose | enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules | Homo sapiens | UDP-glucose | - |
r | |
UDP-GalNAc | - |
Homo sapiens | UDP-GlcNAc | - |
r | |
UDP-GalNAc | enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules | Homo sapiens | UDP-GlcNAc | - |
r |
Synonyms | Comment | Organism |
---|---|---|
GalE | - |
Escherichia coli |
GalE | - |
Homo sapiens |
UDP-galactose 4'-epimerase | - |
Escherichia coli |
UDP-galactose 4'-epimerase | - |
Homo sapiens |