Application | Comment | Organism |
---|---|---|
drug development | serine racemase inhibitors are therapeutic candidates for the treatment of neurodegenerative disorders and epileptic states | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-acetamidoanilino)-1-oxopropan-2-yl 3-[(2-chlorophenyl)sulfanyl]propanoate | - |
Homo sapiens | |
1-(4-ethoxyanilino)-1-oxopropan-2-yl 3-[(2-chlorophenyl)sulfanyl]propanoate | - |
Homo sapiens | |
1-anilino-1-oxopropan-2-yl 3-[(2-chlorophenyl)sulfanyl]propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-(2-fluorophenoxy)propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-(phenylsulfanyl)propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-[(2-chlorophenyl)sulfanyl]propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-[(2-fluorophenyl)sulfanyl]propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-[(2-methoxyphenyl)sulfanyl]propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-[(3-methoxyphenyl)sulfanyl]propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 3-[(4-methoxyphenyl)sulfanyl]propanoate | - |
Homo sapiens | |
2-(4-acetamidoanilino)-2-oxoethyl 4-(2-methoxyphenyl)butanoate | - |
Homo sapiens | |
additional information | design, synthesis, and evaluation of inhibitors for wild-type human serine racemase. Serine racemase inhibitors are therapeutic candidates for the treatment of neurodegenerative disorders and epileptic states. No inhibition by 2-(4-acetamidoanilino)-2-oxoethyl 3-[(3-chlorophenyl)sulfanyl]propanoate, N-[2-(4-acetamidoanilino)-2-oxoethyl]-3-[(2-chlorophenyl)sulfanyl]propanamide, N-[2-(4-acetamidoanilino)-2-oxoethyl]-3-[(2-methoxyphenyl)sulfanyl]propanamide, and N-(4-acetamidophenyl)-7-(2-methoxyphenyl)-4-oxoheptanamide | Homo sapiens | |
N-(4-acetamidophenyl)-N2-[3-[(2-chlorophenyl)sulfanyl]propanoyl]alaninamide | - |
Homo sapiens | |
N-(4-acetamidophenyl)-N2-[3-[(2-methoxyphenyl)sulfanyl]propanoyl]alaninamide | - |
Homo sapiens | |
N-(4-acetylphenyl)-2-[(3,4-dichlorophenyl)acetyl]hydrazine-1-carboxamide | - |
Homo sapiens | |
N2-[(4-chlorophenoxy)acetyl]-N-(2,3,4-trifluorophenyl)glycinamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | Homo sapiens | - |
D-serine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9GZT4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Homo sapiens | D-serine | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | most of the endogenous free D-serine (about 90%) in the brain is produced by serine racemase. D-Serine in the brain is involved in neurodegenerative disorders and epileptic states as an endogenous co-agonist of the NMDA-type glutamate receptor | Homo sapiens |