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Literature summary for 4.6.1.2 extracted from
- Bicarbonate modulates photoreceptor guanylate cyclase (ROS-GC) catalytic activity (2015), J. Biol. Chem., 290, 11052-11060 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| hydrogencarbonate | ED50 value of 27 mM. Stimulation is more powerful in the presence of activating protein GCAP1 or GCAP2 at low concentrations of Ca2+ | Bos taurus |  |
| hydrogencarbonate | ED50 value of 39 mM. When applied to retinal photoreceptors, hydrogencarbonate enhances the circulating current, decreases sensitivity to flashes, and accelerates flash response kinetics | Bos taurus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection of COS-7 cell | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | O02740 | isoform GC2 | - |
| Bos taurus | P55203 | isoform GC1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Bos taurus | 3',5'-cGMP + diphosphate | - |
? | |
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