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Literature summary for 4.6.1.2 extracted from

  • Yang, S.; Zhang, J.; Ji, K.; Jiao, D.; Fan, R.; Dong, C.
    Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep (2016), Acta Histochem., 118, 219-224 .
    View publication on PubMed
Search for more literature for 4.6.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Ovis aries 5737
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additional information protein is additionally localized to intercellular substance of upper hair papilla in hair follicles of white sheep skin and intercellular substance of lower hair bulb and outer root sheath cells in hair follicles of black sheep skin Ovis aries
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Organism

Organism UniProt Comment Textmining
Ovis aries
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-
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Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
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 Ovis aries
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skin expression of soluble guanylate cyclase is significantly higher in white vs. black sheep skin both at the mRNA and protein levels Ovis aries
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General Information

General Information Comment Organism
physiological function overexpression of soluble guanylate cyclase in melanocytes results in decreased expression of key melanogenic genes including microphthalmia transcription factor, tyrosinase, tyrosinase related protein 1, and tyrosinase related protein 2, both at mRNA and protein level. The melanocytes are capable of producing cGMP and cAMP Ovis aries