Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | direct stimulation of cGMP synthesis and activation of mitogen-activated protein kinase signaling pathways underlies the capacity of Mn2+ to augment NF-kappaB-dependent gene expression in astrocytes | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | i.e.ODQ, a sGC inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | Mn2+-stimulated synthesis of cGMP is independent of IFNgamma/TNFalpha in astrocytes | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | Mus musculus C57BL/6 | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | Mus musculus | inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO | ? | - |
? | |
additional information | Mus musculus C57BL/6 | inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Mus musculus C57BL/6 | 3',5'-cyclic GMP + diphosphate | - |
? | |
additional information | inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO | Mus musculus | ? | - |
? | |
additional information | inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Mus musculus |
soluble guanylate cyclase | - |
Mus musculus |