Application | Comment | Organism |
---|---|---|
additional information | intrinsic requirement of guanylate cyclases for stability and/or transport of a set of membrane-associated phototransduction proteins | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | GC1-/-, GC2-/- and GC1/GC2 double knock-out mice, GC1 expression level is maintained in GC2-/- retina and GC2 expression level is maintained in GC1-/- retina. Deletion of GC1 and GC2 renders rod and cone photoreceptors nonfunctional and unstable. In the rod outer segments of guanylate cyclase double knock-out mice, guanylate cyclase-activating proteins 1 and 2, and cyclic GMP phosphodiesterase are undetectable, although rhodopsin and transducin alpha-subunit are mostly unaffected. Outer segment membranes of GC1-/- and GC double knock-out cones are destabilized and devoid of cone transducin (alpha- and gamma-subunits), cone phosphodiesterase, and G protein-coupled receptor kinase 1, whereas cone pigments are present at reduced levels. Down-regulated proteins show normal RNA transcript levels, indicating that down-regulation is posttranslational | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J background | - |
Mus musculus C57/BL6J | - |
C57BL/6J background | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cone | - |
Mus musculus | - |
retina | - |
Mus musculus | - |
retinal rod | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
GC1 | - |
Mus musculus |
GC2 | - |
Mus musculus |
guanylate cyclase 1 | - |
Mus musculus |
guanylate cyclase 2 | - |
Mus musculus |