Application | Comment | Organism |
---|---|---|
medicine | importance of repeated cell divisions in controlling the steady-state amount of GPI-PLCp during differentiation of the African trypanosome | Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
strain ILTat 1.3, strain 427 and strain AnTat 1.1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Trypanosoma brucei | - |
Synonyms | Comment | Organism |
---|---|---|
GPI-phospholipase C | - |
Trypanosoma brucei |
GPI-phospholipase C polypeptide | - |
Trypanosoma brucei |
GPI-PLCp | - |
Trypanosoma brucei |
Organism | Comment | Expression |
---|---|---|
Trypanosoma brucei | during differentiation of bloodstream to insect stage (procyclic), translation GPI-phospholipase C polypeptide mRNA ceases within 8 h of initiating transformation. Reduction of GPI-PLCp in early-stage procyclics is linked to parasite replication | down |
Trypanosoma brucei | expression of GPI-phospholipase C polypeptide in the parasite is restricted to the bloodstream form. Nascent procyclics contain 400fold more GPI-phospholipase C polypeptide than established insect stage. GPI-PLCp is retained in strains that fail to replicate after differentiation of the bloodstream to the procyclic form | up |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of GPI-phospholipase C polypeptide is associated with sustained replication of nascent procyclics | Trypanosoma brucei |
physiological function | in monomorphic ILTat 1.3 strain, total GPI-phospholipase C polypeptide enzyme activity (per cell) remains constant for 72 h after initiation of transformation. GPI-phospholipase C polypeptide remains in AnTat 1.1 through differentiation, when variant surface glycoprotein is lost and procyclin is expressed on the cell surface | Trypanosoma brucei |