Literature summary for 4.6.1.1 extracted from

Luebker, C.; Urbauer, R.; Moskovitz, J.; Dove, S.; Weisemann, J.; Fedorova, M.; Urbauer, J.; Seifert, R.
Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin (2015), Biochem. Pharmacol., 93, 196-209 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	calmodulin activation of isoform Adcy1 can be regulated by selctive oxidation of the C-terminal Met residues in calmodulin, and by two N-terminal Met residues, M36 and M51. CaM with all Met residues oxidized is unable to activate the enzyme	Bos taurus

Application

Application	Comment	Organism
medicine	isoform Adcy1 catalytic activity can be delicately adjusted by mediating calmodulin activation of Adcy1 by reversible Met oxidation in calmodulin	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P19754	isoform Adcy1	-

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Release 2023.1 (January 2023)