Application | Comment | Organism |
---|---|---|
medicine | AC5 is the major AC isoform mediating acute beta-adrenergic stimulation, AC5 plays a major role in L-type Ca2+ currents activation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | AC5-deficient (AC5-/-) mice, reduction of basal L-type Ca2+ currents is significantly less pronounced than in wild-type myocytes, isoproterenol effects on L-type Ca2+ currents are mitigated | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio-]triphosphate | inhibits AC5, reduces basal L-type Ca2+ currents as a function of time, significantly and almost completely diminishes the increase of L-type Ca2+ currents due to isoproterenol, basal and isoproterenol-stimulated inhibition of L-type Ca2+ currents is concentration-dependent | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57/BL6 mice | - |
Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Mus musculus C57BL/6 | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC5 | - |
Mus musculus |