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Literature summary for 4.4.1.1 extracted from

  • Bridges, C.C.; Krasnikov, B.F.; Joshee, L.; Pinto, J.T.; Hallen, A.; Li, J.; Zalups, R.K.; Cooper, A.J.
    New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine gamma-lyase (2012), Arch. Biochem. Biophys., 517, 20-29.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuribenzoate
-
Rattus norvegicus
CH3-Hg-S-Cys the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor Rattus norvegicus
Cys-S-Hg-S-Cys the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor Rattus norvegicus
HgCl2 a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase Rattus norvegicus
Iodosobenzoate
-
Rattus norvegicus
additional information extent to which inactivation occurs with the various mercury-containing compounds in descending order: Cys-S-Hg-S-Cys, HgCl2, CH3Hg-S-Cys Rattus norvegicus
N-ethylmaleimide
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
HgCl2 a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cystathionine + H2O Rattus norvegicus
-
2-oxobutyrate + L-cysteine + NH3
-
?
L-cystine + H2O Rattus norvegicus
-
pyruvate + NH3 + L-thiocysteine
-
?
L-homoserine Rattus norvegicus the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term 2-oxobutyrate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
24
-
purified liver enzyme, pH 7.4, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystathionine + H2O
-
Rattus norvegicus 2-oxobutyrate + L-cysteine + NH3
-
?
L-cystine + H2O
-
Rattus norvegicus pyruvate + NH3 + L-thiocysteine
-
?
L-homoserine the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term Rattus norvegicus 2-oxobutyrate + NH3
-
?
additional information no activity with L-methionine Rattus norvegicus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus