Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloromercuribenzoate | - |
Rattus norvegicus | |
CH3-Hg-S-Cys | the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor | Rattus norvegicus | |
Cys-S-Hg-S-Cys | the cysteine S-conjugate of Hg2+ is a potent irreversible enzyme inhibitor | Rattus norvegicus | |
HgCl2 | a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase | Rattus norvegicus | |
Iodosobenzoate | - |
Rattus norvegicus | |
additional information | extent to which inactivation occurs with the various mercury-containing compounds in descending order: Cys-S-Hg-S-Cys, HgCl2, CH3Hg-S-Cys | Rattus norvegicus | |
N-ethylmaleimide | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
HgCl2 | a potent irreversible enzyme inhibitor, but HgCl2 is also a strong inactivator of cystathionine gamma-lyase | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cystathionine + H2O | Rattus norvegicus | - |
2-oxobutyrate + L-cysteine + NH3 | - |
? | |
L-cystine + H2O | Rattus norvegicus | - |
pyruvate + NH3 + L-thiocysteine | - |
? | |
L-homoserine | Rattus norvegicus | the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term | 2-oxobutyrate + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
24 | - |
purified liver enzyme, pH 7.4, 37°C | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cystathionine + H2O | - |
Rattus norvegicus | 2-oxobutyrate + L-cysteine + NH3 | - |
? | |
L-cystine + H2O | - |
Rattus norvegicus | pyruvate + NH3 + L-thiocysteine | - |
? | |
L-homoserine | the hydrolysis reaction is balanced by elimination of H2O, the net reaction does not include an H2O term | Rattus norvegicus | 2-oxobutyrate + NH3 | - |
? | |
additional information | no activity with L-methionine | Rattus norvegicus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |