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Literature summary for 4.4.1.1 extracted from

  • Kandil, S., Brennan, L., McBean, G.J.
    Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells (2010), Neurochem. Int., 56, 611-619.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
DL-propargylglycine
-
Homo sapiens
DL-propargylglycine
-
Mus musculus
DL-propargylglycine
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cystathionine + H2O Mus musculus
-
L-homocysteine + pyruvate + NH3
-
?
L-cystathionine + H2O Homo sapiens
-
L-homocysteine + pyruvate + NH3
-
?
L-cystathionine + H2O Rattus norvegicus
-
L-homocysteine + pyruvate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
C6 glioma cell
-
Rattus norvegicus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystathionine + H2O
-
Mus musculus L-homocysteine + pyruvate + NH3
-
?
L-cystathionine + H2O
-
Homo sapiens L-homocysteine + pyruvate + NH3
-
?
L-cystathionine + H2O
-
Rattus norvegicus L-homocysteine + pyruvate + NH3
-
?

Synonyms

Synonyms Comment Organism
CTH
-
Mus musculus
CTH
-
Homo sapiens
CTH
-
Rattus norvegicus
cystathionine-gamma-lyase
-
Mus musculus
cystathionine-gamma-lyase
-
Homo sapiens
cystathionine-gamma-lyase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mus musculus
pyridoxal 5'-phosphate
-
Homo sapiens
pyridoxal 5'-phosphate
-
Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase. Expression of cystathionine-gamma-lyase is 1.5fold increased following incubation of the cells with diethylmaleate for 3 h. Co-incubation of C6 cells with diethylmaleate and the JNK-inhibitor, SP600125, abolishes the increase in expression of cystathionine-gamma-lyase that is observed in the presence of diethylmaleate alone up