Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-propargylglycine | - |
Homo sapiens | |
DL-propargylglycine | - |
Mus musculus | |
DL-propargylglycine | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cystathionine + H2O | Mus musculus | - |
L-homocysteine + pyruvate + NH3 | - |
? | |
L-cystathionine + H2O | Homo sapiens | - |
L-homocysteine + pyruvate + NH3 | - |
? | |
L-cystathionine + H2O | Rattus norvegicus | - |
L-homocysteine + pyruvate + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
C6 glioma cell | - |
Rattus norvegicus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cystathionine + H2O | - |
Mus musculus | L-homocysteine + pyruvate + NH3 | - |
? | |
L-cystathionine + H2O | - |
Homo sapiens | L-homocysteine + pyruvate + NH3 | - |
? | |
L-cystathionine + H2O | - |
Rattus norvegicus | L-homocysteine + pyruvate + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTH | - |
Mus musculus |
CTH | - |
Homo sapiens |
CTH | - |
Rattus norvegicus |
cystathionine-gamma-lyase | - |
Mus musculus |
cystathionine-gamma-lyase | - |
Homo sapiens |
cystathionine-gamma-lyase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus | |
pyridoxal 5'-phosphate | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase. Expression of cystathionine-gamma-lyase is 1.5fold increased following incubation of the cells with diethylmaleate for 3 h. Co-incubation of C6 cells with diethylmaleate and the JNK-inhibitor, SP600125, abolishes the increase in expression of cystathionine-gamma-lyase that is observed in the presence of diethylmaleate alone | up |