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Literature summary for 4.4.1.1 extracted from

  • Zhong, G.Z.; Yang, X.C.; Jia, L.P.; Chen, F.R.; Cui, M..
    Inhibition of the cystathionine-gamma-lyase/hydrogen sulfide pathway in rat vascular smooth muscle cells by cobalt-60 gamma radiation (2009), Chin. Med. J., 122, 326-330.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + H2O
-
Rattus norvegicus sulfide + NH3 + pyruvate
-
?
L-homoserine + H2O
-
Rattus norvegicus 2-oxobutanoate + NH3 + H2O
-
?

Synonyms

Synonyms Comment Organism
CSE
-
Rattus norvegicus
cystathionine-gamma-lyase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus cobalt-60 gamma radiation at doses of 14 Gy and 25 Gy decrease the cystathionine-gamma-lyase activity by 15.1% and 20.5%, respectively, and cystathionine-gamma-lyase mRNA expression by 29.3% and 38.2%, respectively down