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Literature summary for 4.4.1.1 extracted from

  • Li, L.; Whiteman, M.; Moore, P.K.
    Dexamethasone inhibits lipopolysacharide-induced hydrogen sulfide biosynthesis in intact cells and in an animal model of endotoxic shock (2008), J. Cell. Mol. Med., 13, 2684-2692.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine inhibition of CSE expression and reduction in formation of the pro-inflammatory component of H(2)S activity contributes to the anti-inflammatory effect of dexamethasone in endotoxic shock. Whether H(2)S plays a part in the anti-inflammatory effect of this steroid in other forms of inflammation such as arthritis or asthma warrants further study Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information dexamethasone reduces the expression of cystathionine gamma lyase. Also reduces LPS-induced upregulation of CSE in fetal liver cells. 6-amino-4-(4-phenoxyphenylethylamino) quinazoline (QNZ) 10 nM, a selective inhibitor of transcription via the NF-kappaB pathway, abolishs lipopolysaccharide-induced upregulation of CSE expression Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Synonyms

Synonyms Comment Organism
CSE
-
Rattus norvegicus
cystathionine gamma lyase
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Rattus norvegicus