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Literature summary for 4.4.1.1 extracted from

  • Feng, X.; Chen, Y.; Zhao, J.; Tang, C.; Jiang, Z.; Geng, B.
    Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator (2009), Biochem. Biophys. Res. Commun., 380, 153-159.
    View publication on PubMed

Application

Application Comment Organism
additional information H2S might be a novel insulin resistance regulator Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Beta-cyano-L-alanine pretreating adiopose tissues with the CSE inhibitor beta-cyano-L-alanine (BCA) (2 mmol/l) for 20 min significantly decreased the endogenous H2S production by 89%, as compared with controls Rattus norvegicus
DL-propargylglycine pretreating adiopose tissues with the CSE inhibitor DL-propargylglycine (PPG) (10 mmol/l) for 20 min significantly decreased the endogenous H2S production by 85%, as compared with controls Rattus norvegicus
additional information administration of CSE inhibitors enhances the glucose uptake of adipocytes Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
Western blot analysis, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
76 male Sprague-Dawley rats (200-250 g), 96 different age rats (from 1 month to 12 months old) and insulin-resistant animals
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Rattus norvegicus
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kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
preadipocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + H2O
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Rattus norvegicus sulfide + NH3 + pyruvate
-
?

Synonyms

Synonyms Comment Organism
CSE
-
Rattus norvegicus
cystathionine gamma lyase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus