Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(RS)-dimethyl-(4-methylcyclohex-3-en-1-yl)sulfonium iodide | - |
Origanum majorana | |
(RS)-methyl-(4-methylpent-3-en-1-yl)vinyl sulfonium perchlorate | - |
Origanum majorana | |
6,7-dihydrogeranyl diphosphate | competitive | Origanum majorana |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
(3S)-linalyl diphosphate | pH 7.0, 30°C | Origanum majorana | |
0.0019 | - |
geranyl diphosphate | pH 7.0, 30°C | Origanum majorana | |
0.0027 | - |
(3R)-linalyl diphosphate | pH 7.0, 30°C | Origanum majorana | |
0.0045 | - |
6,7-dihydrogeranyl diphosphate | pH 7.0, 30°C | Origanum majorana | |
0.0105 | - |
neryl diphosphate | pH 7.0, 30°C | Origanum majorana |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | absolute requirement for divalent cation in the reaction with 6,7-dihydrogeranyl diphosphate, preference for Mn2+ over Mg2+ | Origanum majorana | |
Mn2+ | absolute requirement for divalent cation in the reaction with 6,7-dihydrogeranyl diphosphate, preference for Mn2+ over Mg2+ | Origanum majorana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Origanum majorana | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Origanum majorana |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
geranyl diphosphate + H2O = sabinene hydrate + diphosphate | both cis- and trans-isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction, mechanism and stereochemistry | Origanum majorana |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Origanum majorana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3R)-linalyl diphosphate + H2O | - |
Origanum majorana | (1S,2S,4R)-(E)-sabinene hydrate + diphosphate | - |
? | |
(3S)-linalyl diphosphate | - |
Origanum majorana | (1R,2R,4S)-(E)-sabinene hydrate + diphosphate | - |
? | |
2,3-methanogeranyl diphosphate + H2O | at 1.5% of the rate of conversion of geranyl diphosphate to sabinene hydrate, noncyclizable substrate analog of geranyl diphosphate | Origanum majorana | ? | - |
? | |
6,7-dihydrogeranyl diphosphate + H2O | noncyclizable substrate analog of geranyl diphosphate | Origanum majorana | 6,7-dihydromyrcene + ? | - |
? | |
geranyl diphosphate | - |
Origanum majorana | sabinene hydrate + diphosphate | the configuration at c1 of geranyl diphosphate is retained in the enzymatic conversion to (+)-cis and (+)-trans-sabinene hydrate | ? | |
geranyl diphosphate | - |
Origanum majorana | sabinene hydrate + diphosphate | both cis- and trans-isomers of sabinene hydrate are formed | ? | |
linalyl diphosphate | 3R- and 3S-configuration | Origanum majorana | sabinene hydrate + diphosphate | cis- and trans-sabinene hydrate | ? | |
neryl diphosphate | - |
Origanum majorana | sabinene hydrate + diphosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
(RS)-methyl-(4-methylpent-3-en-1-yl)vinyl sulfonium perchlorate | pH 7.0, 30°C | Origanum majorana | |
0.0028 | - |
(RS)-dimethyl-(4-methylcyclohex-3-en-1-yl)sulfonium iodide | pH 7.0, 30°C | Origanum majorana | |
0.0042 | - |
6,7-dihydrogeranyl diphosphate | pH 7.0, 30°C | Origanum majorana |