Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2R,3S-Isocitrate | competitive | Yarrowia lipolytica | |
iodoacetate | weak | Yarrowia lipolytica | |
PCMB | weak | Yarrowia lipolytica | |
threo-DL-Isocitrate | weak | Yarrowia lipolytica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate | Yarrowia lipolytica | the enzyme is involved in methylcitric acid cycle for propionate metabolism | ? | - |
? | |
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate | Yarrowia lipolytica | constitutively synthesized, no regulatory function in the methylcitric acid cycle. The enzyme is supposed to have evolutionarily developed from a hypothetical and prototypical isocitrate dehydratase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yarrowia lipolytica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate | - |
Yarrowia lipolytica | (Z)-But-2-ene-1,2,3-tricarboxylate + H2O | - |
? | |
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate | the enzyme is involved in methylcitric acid cycle for propionate metabolism | Yarrowia lipolytica | ? | - |
? | |
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate | constitutively synthesized, no regulatory function in the methylcitric acid cycle. The enzyme is supposed to have evolutionarily developed from a hypothetical and prototypical isocitrate dehydratase | Yarrowia lipolytica | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no cofactor required | Yarrowia lipolytica |