Literature summary for 4.2.1.49 extracted from

Cabral, M.P.; Soares, N.C.; Aranda, J.; Parreira, J.R.; Rumbo, C.; Poza, M.; Valle, J.; Calamia, V.; Lasa, I.; Bou, G.
Proteomic and functional analyses reveal a unique lifestyle for Acinetobacter baumannii biofilms and a key role for histidine metabolism (2011), J. Proteome Res., 10, 3399-3417.

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Protein Variants

Protein Variants	Comment	Organism
additional information	construction of both a mutant with target locus inactivation of urocanase, DELTAhut, and a complemented strain, DELTAhut-c. The complemented strain show increased biofilm production when compared with the mutant strain	Acinetobacter baumannii

Organism

Organism	UniProt	Comment	Textmining
Acinetobacter baumannii	-	-	-
Acinetobacter baumannii ATCC 17978	-	-	-

Synonyms

Synonyms	Comment	Organism
Urocanase	-	Acinetobacter baumannii

General Information

General Information	Comment	Organism
malfunction	L-His uptake triggers biofilms efficiently in wild-type Acinetobacter baumannii, but no effect is observed in urocanase and OmpA mutants, while a slight increase is observed in a CarO-deficient strain	Acinetobacter baumannii
metabolism	urocanase plays a central functional role in metabolism of histidine. The histidine degradation pathway occurs via urocanase and leads to the production of purines and pyrimidines	Acinetobacter baumannii

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Release 2023.1 (January 2023)