Literature summary for 4.2.1.175 extracted from

Dodd, D.; Spitzer, M.; Van Treuren, W.; Merrill, B.; Hryckowian, A.; Higginbottom, S.; Le, A.; Cowan, T.; Nolan, G.; Fischbach, M.; Sonnenburg, J.
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites (2017), Nature, 551, 648-652 .

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Application

Application	Comment	Organism
medicine	in mice colonized by a wild-type Clostridium sporogenes strain, the mean indolepropionic acid concentration is around 80 microM, but in mice colonized with theFfldC mutant, indolepropionic acid is undetectable. Animals colonized by the FldC mutant exhibit significantly elevated frequencies of circulating myeloid cells, including neutrophils and classical (Ly6C+) monocytes, as well as increased antigen-experienced effector/memory T cells. Mice colonized by the FldC mutant strain show a significant increase in circulating Clostridium sporogenes-specific IgG	Clostridium sporogenes

Organism

Organism	UniProt	Comment	Textmining
Clostridium sporogenes	Q93AL9 and Q93AL8	Q93AL9 i.e. alpha-subunit FldB, Q93AL8 i.e. beta-subunit FldC	-

Synonyms

Synonyms	Comment	Organism
FldC	-	Clostridium sporogenes

General Information

General Information	Comment	Organism
physiological function	FldC is essential for the reductive metabolism of aromatic amino acids phenylalanine, tyrosine and tryptophan	Clostridium sporogenes

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Release 2023.1 (January 2023)