Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.99.5 extracted from

  • Warui, D.M.; Pandelia, M.E.; Rajakovich, L.J.; Krebs, C.; Bollinger, J.M.; Booker, S.J.
    Efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase (2015), Biochemistry, 54, 1006-1015 .
    View publication on PubMed
Search for more literature for 4.1.99.5

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a long-chain aldehyde + O2 + 2 NADPH + 2 H+ Nostoc punctiforme
-
 an alkane + formate + H2O + 2 NADP+
-
 ?
a long-chain aldehyde + O2 + 2 NADPH + 2 H+ Nostoc punctiforme ATCC 29133 / PCC 73102
-
 an alkane + formate + H2O + 2 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Nostoc punctiforme B2J1M1
-
-
Nostoc punctiforme ATCC 29133 / PCC 73102 B2J1M1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a long-chain aldehyde + O2 + 2 NADPH + 2 H+
-
 Nostoc punctiforme an alkane + formate + H2O + 2 NADP+
-
 ?
a long-chain aldehyde + O2 + 2 NADPH + 2 H+
-
 Nostoc punctiforme ATCC 29133 / PCC 73102 an alkane + formate + H2O + 2 NADP+
-
 ?

Synonyms

Synonyms Comment Organism
ADO
-
 Nostoc punctiforme
aldehyde-deformylating oxygenase
-
 Nostoc punctiforme

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Nostoc punctiforme

General Information

General Information Comment Organism
metabolism efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase in a two-step pathway consisting of an acyl-acyl carrier protein (ACP) reductase (AAR) and an aldehyde-deformylating oxygenase (ADO) allowing various cyanobacteria to convert long-chain fatty acids into hydrocarbons. When the aldehyde substrate is supplied to ADO by AAR, efficient in vitro turnover is observed in the absence of solubilizing agents, even with insoluble substrates like octadec(a/e)nal, overview. AAR and ADO form a tight isolable complex with a Kd of 0.003 mM. The interaction between AAR and ADO facilitates either direct transfer of the aldehyde product of AAR to ADO or formation of the aldehyde product in a microenvironment allowing for its efficient uptake by ADO Nostoc punctiforme
physiological function aldehyde-deformylating oxygenase (ADO) is an important enzyme involved in the biosynthetic pathway of fatty alk(a/e)nes in cyanobacteria. ADO transforms the fatty aldehyde to a Cn-1 hydrocarbon and C1-derived formate Nostoc punctiforme