Literature summary for 4.1.3.4 extracted from

Dong, Y.; Zhang, J.; Xu, R.; Lv, X.; Wang, L.; Sun, A.; Wei, D.
Insertion mutation in HMG-CoA lyase increases the production yield of MPA through Agrobacterium tumefaciens-mediated transformation (2016), J. Microbiol. Biotechnol., 26, 1924-1932 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli DH5alpha cells	Penicillium brevicompactum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-3-Hydroxy-3-methylglutaryl-CoA	Penicillium brevicompactum	-	Acetyl-CoA + acetoacetate	-	?
(S)-3-Hydroxy-3-methylglutaryl-CoA	Penicillium brevicompactum ATCC 16024	-	Acetyl-CoA + acetoacetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Penicillium brevicompactum	-	-	-
Penicillium brevicompactum ATCC 16024	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-3-Hydroxy-3-methylglutaryl-CoA	-	Penicillium brevicompactum	Acetyl-CoA + acetoacetate	-	?
(S)-3-Hydroxy-3-methylglutaryl-CoA	-	Penicillium brevicompactum ATCC 16024	Acetyl-CoA + acetoacetate	-	?

Synonyms

Synonyms	Comment	Organism
beta-hydroxy-beta-methylglutaryl-CoA lyase	-	Penicillium brevicompactum
HMG-CoA lyase	-	Penicillium brevicompactum

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Release 2023.1 (January 2023)