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Literature summary for 4.1.1.72 extracted from

  • Islam, M.M.; Nautiyal, M.; Wynn, R.M.; Mobley, J.A.; Chuang, D.T.; Hutson, S.M.
    The branched chain amino acid (BCAA) metabolon: Interaction of glutamate dehydrogenase with the mitochondrial branched chain aminotransferase (BCATm) (2010), J. Biol. Chem., 285, 265-276.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.72

Activating Compound

Activating Compound Comment Organism Structure
additional information GDH1 alone does not have a significant effect on BCKDC activity. However, addition of GDH1 and glutamate enhance the calculated kcat value by 40-45% with mitochondrial branched-chain aminotransferase present when compared with BCKDC plus branched-chain alpha-keto acids alone Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein when the E1alpha subunit is fully phosphorylated, overall BCKDC activity is zero Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
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additional information BCKDC proteins in the metabolon are found in all tissues except skeletal muscle, which harbors only the five subunits Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mitochondrial branched-chain aminotransferase binds to the E1 decarboxylase of BCKDC, forming a metabolon that allows channeling of branched-chain alpha-keto acids from mitochondrial branched-chain aminotransferase to E1 Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
BCKDC
-
 Rattus norvegicus
branched-chain alpha-ketoacid dehydrogenase complex the protein complex also contains glutamate dehydrogenase 1, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1, pyruvate carboxylase, and BCKDC kinase Rattus norvegicus