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Literature summary for 4.1.1.65 extracted from

  • Gulshan, K.; Shahi, P.; Moye-Rowley, W.S.
    Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance (2010), Mol. Biol. Cell, 21, 443-455.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
Pdr17 the presence of a phosphatidylinositol transfer protein called Pdr17 is required for Psd2 function Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome Psd2 Saccharomyces cerevisiae 5768
-
mitochondrion PSD1 Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Phosphatidyl-L-serine
-
 Saccharomyces cerevisiae Phosphatidylethanolamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PSD1
-
 Saccharomyces cerevisiae
PSD2
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction loss of Psd2 causes cells to acquire sensitivity to cadmium even though Psd1 remains intact, loss of Psd2 causes a specific reduction in vacuolar membrane phosphatidylethanolamine levels, whereas total phosphatidylethanolamine levels are not significantly affected Saccharomyces cerevisiae
physiological function the mitochondrial Psd1 provides roughly 70% of the phosphatidylethanolamine biosynthesis in the cell with Psd2 carrying out the remainder, Psd2 action enhances Ycf1-dependent transport activity Saccharomyces cerevisiae