Cloned (Comment) | Organism |
---|---|
expression in Pichia pastoris | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
molecular docking of inhibitor 3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid. The 2-thiophene ring fits the hydrophobic cleft defined by the Trp191 and Met180 residues | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid | potent and selective inhibitor. Treatment of primary hepatocytes significantly increases intracellular NAD+ levels. compound exhibits good solubility with low permeability of cells and no inhibition of cytochrome P450s | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TDX5 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ACMSD | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000013 | - |
37°C, pH not specified in the publication | Homo sapiens | 3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid |
General Information | Comment | Organism |
---|---|---|
physiological function | ACMSD inhibition increases de novo NAD+ biosynthesis | Homo sapiens |