Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
D306A | low activity | Rattus norvegicus |
D306E | low activity | Rattus norvegicus |
D306N | low activity | Rattus norvegicus |
K208A | low activity | Rattus norvegicus |
K23A | no activity | Rattus norvegicus |
K27A | low activity | Rattus norvegicus |
R154A | low activity | Rattus norvegicus |
R162A | low activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol | - |
Rattus norvegicus | |
1-(diphosphenyloxy)-3-methylpentan-3-ol | - |
Rattus norvegicus | |
1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol | - |
Rattus norvegicus | |
2,2-difluoromevalonate 5-diphosphate | - |
Rattus norvegicus | |
2-fluoromevalonate 5-diphosphate | irreversible inhibitor | Rattus norvegicus | |
3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate | - |
Rattus norvegicus | |
4-(diphosphenyloxy)-2-methylbutan-2-ol | - |
Rattus norvegicus | |
4-(diphosphenyloxy)-2-phenylbutan-2-ol | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.036 | - |
5-diphosphomevalonate | wild type enzyme | Rattus norvegicus | |
0.53 | - |
ATP | wild type enzyme | Rattus norvegicus | |
0.75 | - |
5-diphosphomevalonate | mutant enzyme K27A | Rattus norvegicus | |
0.92 | - |
5-diphosphomevalonate | mutant enzyme R154A | Rattus norvegicus | |
1.4 | - |
ATP | mutant enzyme R154A | Rattus norvegicus | |
1.87 | - |
ATP | mutant enzyme K27A | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
nickel metal affinity column chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5-diphosphomevalonate | - |
Rattus norvegicus | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MDD | - |
Rattus norvegicus |
mevalonate 5'-diphosphate decarboxylase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0075 | - |
- |
Rattus norvegicus | 2,2-difluoromevalonate 5-diphosphate | |
0.02 | - |
- |
Rattus norvegicus | 3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate | |
0.05 | - |
- |
Rattus norvegicus | 1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol | |
0.06 | - |
- |
Rattus norvegicus | 4-(diphosphenyloxy)-2-methylbutan-2-ol | |
0.08 | - |
- |
Rattus norvegicus | 1-(diphosphenyloxy)-3-methylpentan-3-ol | |
0.12 | - |
- |
Rattus norvegicus | 1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol | |
0.14 | - |
- |
Rattus norvegicus | 4-(diphosphenyloxy)-2-phenylbutan-2-ol |