Protein Variants | Comment | Organism |
---|---|---|
additional information | the mutant allele of Tdc1, Tdc1f03311, reduces expression of the mature Tdc1 transcript by greater than 100fold | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Tyrosine | Drosophila melanogaster | - |
Tyramine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
malpighian tubule | the non-neuronal isoform of TDC, Tdc1, is expressed in the principal cells of the Malpighian tubule | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Tyrosine | - |
Drosophila melanogaster | Tyramine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TDC | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | Malpighian tubules isolated from Tdc1f03311 homozygous flies show no significant depolarization of their transepithelial potential or diuresis in response to tyrosine while retaining normal sensitivity to tyramine, the null mutant allele of the neuronal TDC isoform Tdc2 has no effect on either tyrosine or tyramine sensitivity | Drosophila melanogaster |
physiological function | synthesis of tyramine by Tdc1 in the principal cells of the Malpighian tubule is required for physiological responses to tyrosine | Drosophila melanogaster |