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Literature summary for 4.1.1.22 extracted from
- Purification and properties of pyridoxal-5'-phosphate-dependent histidine decarboxylase from Klebsiella planticola and Enterobacter aerogenes (1987), J. Bacteriol., 169, 3963-3968.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-Fluoromethylhistidine | - |
Klebsiella aerogenes |  |
| alpha-Fluoromethylhistidine | - |
Morganella morganii | |
| alpha-Fluoromethylhistidine | - |
Raoultella planticola | |
| alpha-Methylhistidine | - |
Klebsiella aerogenes | |
| alpha-Methylhistidine | - |
Morganella morganii | |
| alpha-Methylhistidine | - |
Raoultella planticola | |
| carnosine | - |
Klebsiella aerogenes | |
| carnosine | - |
Morganella morganii | |
| carnosine | - |
Raoultella planticola | |
| Cyanoborohydride | - |
Morganella morganii | |
| dithiothreitol | - |
Klebsiella aerogenes | |
| dithiothreitol | - |
Morganella morganii | |
| dithiothreitol | - |
Raoultella planticola | |
| Histidine methyl ester | - |
Klebsiella aerogenes | |
| Histidine methyl ester | - |
Raoultella planticola | |
| Hydrazine sulfate | - |
Klebsiella aerogenes | |
| Hydrazine sulfate | - |
Raoultella planticola | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
L-His | - |
Morganella morganii | |
| 2.2 | - |
L-His | - |
Klebsiella aerogenes | |
| 2.4 | - |
L-His | - |
Raoultella planticola | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42500 | - |
2 * and 4 * 42500, SDS-PAGE | Raoultella planticola |
| 42500 | - |
4 * and 2 * 42500, SDS-PAGE | Raoultella planticola |
| 50000 | - |
2 * 50000, SDS-PAGE | Klebsiella aerogenes |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella aerogenes | - |
- |
- |
| Morganella morganii | - |
- |
- |
| Morganella morganii AM-15 | - |
- |
- |
| Raoultella planticola | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Klebsiella aerogenes |
- |
Raoultella planticola |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 121 | - |
- |
Klebsiella aerogenes |
| 123 | - |
- |
Raoultella planticola |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-His | - |
Klebsiella aerogenes | Histamine + CO2 | - |
? | |
| L-His | - |
Morganella morganii | Histamine + CO2 | - |
? | |
| L-His | - |
Raoultella planticola | Histamine + CO2 | - |
? | |
| L-His | - |
Morganella morganii AM-15 | Histamine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * and 4 * 42500, SDS-PAGE | Raoultella planticola |
| dimer | 2 * 50000, SDS-PAGE | Klebsiella aerogenes |
| tetramer | - |
Morganella morganii |
| tetramer | 4 * and 2 * 42500, SDS-PAGE | Raoultella planticola |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Morganella morganii |
| 6.5 | - |
- |
Raoultella planticola |
| 6.5 | - |
- |
Klebsiella aerogenes |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Morganella morganii | |
| pyridoxal 5'-phosphate | contains 1 mol of pyridoxal 5'-phosphate per mol of subunit | Raoultella planticola | |
| pyridoxal 5'-phosphate | contains 1 mol of pyridoxal 5'-phosphate per mol of subunit | Klebsiella aerogenes | |
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