Any feedback?
Literature summary for 4.1.1.20 extracted from
- Control of lysine biosynthesis in Bacillis subtilis: inhibition of diaminopimelate decarboxylase by lysine (1975), J. Bacteriol., 121, 20-28.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | activates | Bacillus subtilis |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-Lysine | - |
Bacillus subtilis | |
| L-2,4-diaminobutyrate | - |
Bacillus subtilis | |
| L-lysine | involved in sequential feedback inhibition, pH-dependent | Bacillus subtilis | |
| L-ornithine | - |
Bacillus subtilis | |
| L-S-aminoethylcysteine | - |
Bacillus subtilis | |
| n-butylamine | - |
Bacillus subtilis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
meso-2,6-diaminoheptanedioate | - |
Bacillus subtilis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activates | Bacillus subtilis | |
| Na+ | activates | Bacillus subtilis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 105000 | - |
gel filtration | Bacillus subtilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| meso-2,6-Diaminoheptanedioate | Bacillus subtilis | lysine biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Brevibacterium sp. | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| meso-2,6-Diaminoheptanedioate | - |
Bacillus subtilis | L-Lysine + CO2 | - |
? | |
| meso-2,6-Diaminoheptanedioate | - |
Brevibacterium sp. | L-Lysine + CO2 | - |
? | |
| meso-2,6-Diaminoheptanedioate | lysine biosynthesis | Bacillus subtilis | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
enzyme assay at | Bacillus subtilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Bacillus subtilis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | more than half-maximal activity between 7.5 and pH 9.0 | Bacillus subtilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | Km: 0.002 mM | Bacillus subtilis | |
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