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Literature summary for 4.1.1.111 extracted from

  • Palmer, D.J.; Schroeder, S.; Lawrence, A.D.; Deery, E.; Lobo, S.A.; Saraiva, L.M.; McLean, K.J.; Munro, A.W.; Ferguson, S.J.; Pickersgill, R.W.; Brown, D.G.; Warren, M.J.
    The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway (2014), Mol. Microbiol., 93, 247-261.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.111

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichioa coli Methanosarcina barkeri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
siroheme Methanosarcina barkeri the enzyme is involved in the alternative heme biosynthesis pathway (in bacteria and archaea) 12,18-didecarboxysiroheme + 2 CO2
-
 ?
siroheme Methanosarcina barkeri DSM 804 the enzyme is involved in the alternative heme biosynthesis pathway (in bacteria and archaea) 12,18-didecarboxysiroheme + 2 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina barkeri Q46CH6 and Q46CH5 Q46CH6: subunit AhbA, Q46CH5: subunit AhbB
-
Methanosarcina barkeri DSM 804 Q46CH6 and Q46CH5 Q46CH6: subunit AhbA, Q46CH5: subunit AhbB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
siroheme the enzyme is involved in the alternative heme biosynthesis pathway (in bacteria and archaea) Methanosarcina barkeri 12,18-didecarboxysiroheme + 2 CO2
-
 ?
siroheme incubations of individual AhbA and AhbB proteins in excess with siroheme yield mixtures with varying levels of siroheme, monodecarboxysiroheme and didecarboxysiroheme. The monodecarboxysiroheme is not characterized further and hence it is not determined as to whether it was due to loss of the carboxylic acid from the C12 or C18 side-chain. AhbA and AhbB together catalyze the conversion of siroheme into 12,18-didecarboxysiroheme Methanosarcina barkeri 12,18-didecarboxysiroheme + 2 CO2
-
 ?
siroheme the enzyme is involved in the alternative heme biosynthesis pathway (in bacteria and archaea) Methanosarcina barkeri DSM 804 12,18-didecarboxysiroheme + 2 CO2
-
 ?
siroheme incubations of individual AhbA and AhbB proteins in excess with siroheme yield mixtures with varying levels of siroheme, monodecarboxysiroheme and didecarboxysiroheme. The monodecarboxysiroheme is not characterized further and hence it is not determined as to whether it was due to loss of the carboxylic acid from the C12 or C18 side-chain. AhbA and AhbB together catalyze the conversion of siroheme into 12,18-didecarboxysiroheme Methanosarcina barkeri DSM 804 12,18-didecarboxysiroheme + 2 CO2
-
 ?

Subunits

Subunits Comment Organism
heterodimer subunit AhbA and subunit AhbB form a heterodimeric heme-binding complex Methanosarcina barkeri

Synonyms

Synonyms Comment Organism
AhbAB
-
 Methanosarcina barkeri
Mbar A1459/Mbar A1460 locus names Methanosarcina barkeri

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Methanosarcina barkeri

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Methanosarcina barkeri

Cofactor

Cofactor Comment Organism Structure
heme subunit AhbA and subunit AhbB form a heterodimeric heme-binding complex Methanosarcina barkeri

General Information

General Information Comment Organism
physiological function the enzyme is involved in the alternative haem biosynthesis pathway (in bacteria and archaea) Methanosarcina barkeri