Literature summary for 3.9.1.3 extracted from

Xu, A.; Li, Y.; Zhao, W.; Hou, F.; Li, X.; Sun, L.; Chen, W.; Yang, A.; Wu, S.; Zhang, B.; Yao, J.; Wang, H.; Huang, J.
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta1 signaling to PI3Kgama/AKT/Rac1 pathway (2018), J. Mol. Med., 96, 119-133 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NRX4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatic stellate cell	enzyme (PHP14) expression is upregulated in fibrotic liver and mainly in hepatic stellate cells	Homo sapiens	-
liver	enzyme (PHP14) expression is upregulated in fibrotic liver and mainly in hepatic stellate cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PHP14	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	PHP14 expression is upregulated in fibrotic liver and mainly in hepatic stellate cells. TGF-beta1 can induce PHP14 expression in hepatic stellate cells accompanied with the activation of hepatic stellate cells	up

General Information

General Information	Comment	Organism
metabolism	PHP14 promotes hepatic stellate cell migration, especially, promotes 3D floating collagen matrices contraction but inhibits stress released matrices contraction. Mechanistically, the PI3Kgamma/AKT/Rac1 pathway is involved in migration regulated by PHP14. Moreover, PHP14 specifically mediates the TGF-beta1 signaling to PI3Kgamma/AKT pathway and regulates HSC migration, and thus participates in liver fibrosis	Homo sapiens
physiological function	the enzyme (PHP14) regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta1 signaling to PI3Kgamma/AKT/Rac1 pathway	Homo sapiens

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Release 2023.1 (January 2023)