Cloned (Comment) | Organism |
---|---|
recombinant expression in Pseudomonas putida strain KT2442 | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4-dichloroisocoumarin | a broad spectrum covalent inhibitor of serine proteases, the structural homologues of 3,4-dichloroisocoumarin, 7-amino-4-chloro-3-methoxy-1H-2-benzopyran and 3-phenyl-1H-2-benzopyran-1-one, show significantly poorer inhibition | Mycobacterium tuberculosis | |
3-phenyl-1H-2-benzopyran-1-one | weak inhibition | Mycobacterium tuberculosis | |
4-(2-aminoethyl)benzenesulfonyl fluoride | weak inhibition | Mycobacterium tuberculosis | |
4-amidinophenylmethanesulfonyl fluoride | weak inhibition | Mycobacterium tuberculosis | |
4-nitrophenyl-4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate | covalent inhibitor | Mycobacterium tuberculosis | |
6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate | weak inhibition | Mycobacterium tuberculosis | |
7-amino-4-chloro-3-methoxy-1H-2-benzopyran | weak inhibition | Mycobacterium tuberculosis | |
benzamidine | weak inhibition | Mycobacterium tuberculosis | |
eserine | an acetylcholinesterase inhibitor | Mycobacterium tuberculosis | |
leupeptin | weak inhibition | Mycobacterium tuberculosis | |
additional information | inhibition of HsaD by serine protease inhibitors. No inhibition by acetylcholinesterase inhibitors edrophonium, tacrine, and pyridostigmine. Consistent with the lack of a cysteine residue in the active site of HsaD, covalent inhibitor nicotinamide does not significantly inhibit HsaD | Mycobacterium tuberculosis | |
neostigmine | an acetylcholinesterase inhibitor | Mycobacterium tuberculosis | |
PMSF | - |
Mycobacterium tuberculosis | |
Trichlorfon | an acetylcholinesterase inhibitor, weak inhibition | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from Pseudomonas putida strain KT2442 | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
HsaD | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
21 | - |
aassay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.63 | - |
pH 7.5, 21°C, recombinant enzyme | Mycobacterium tuberculosis | PMSF |