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Literature summary for 3.6.5.5 extracted from

  • Barylko, B.; Binns, D.; Lin, K.M.; Atkinson, M.A.L.; Jameson, D.M.; Yin, H.L.; Albanesi, J.P.
    Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides (1998), J. Biol. Chem., 273, 3791-3797.
    View publication on PubMed
Search for more literature for 3.6.5.5

Activating Compound

Activating Compound Comment Organism Structure
1-O-(1,2-di-O-palmitoyl-sn-glycerol-3-benzyloxyphosphoryl)-D-myo-inositol 3,4,5-triphosphate activates, binds to the pleckstrin homology domain Bos taurus
Grb2 activates, binds to carboxyl-terminal proline/arginine-rich domain. Grb2 and phosphatidylinositol 4,5-bisphosphate together increase the dynamin GTPase activity up to 4fold higher than that obtained by these activators tested separately Bos taurus
microtubules activates, binds to carboxyl-terminal proline/arginine-rich domain Bos taurus
phosphatidylinositol 3,4-bisphosphate weak activation, binds to the pleckstrin homology domain Bos taurus
phosphatidylinositol-4,5-bisphosphate best activator, binds to the pleckstrin homology domain. Grb2 and phosphatidylinositol 4,5-bisphosphate together increase the dynamin GTPase activity up to 4fold higher than that obtained by these activators tested separately Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Bos taurus enzyme is essential for budding clathrin-coated vesicles from the plasma membrane GDP + phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Bos taurus GDP + phosphate
-
 ?
GTP + H2O enzyme is essential for budding clathrin-coated vesicles from the plasma membrane Bos taurus GDP + phosphate
-
 ?