Crystallization (Comment) | Organism |
---|---|
analysis of crystal structures of ON and OFF aIF2 at resolution of 3.0 and 2.15 A | Saccharolobus solfataricus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | substrate and product binding kinetics and thermodynamics with ON and OFF aIF2 , overview | Saccharolobus solfataricus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Saccharolobus solfataricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Saccharolobus solfataricus | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharolobus solfataricus | Q980A5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Saccharolobus solfataricus | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aIF2 | - |
Saccharolobus solfataricus |
archaeal initiation factor 2 | - |
Saccharolobus solfataricus |
General Information | Comment | Organism |
---|---|---|
additional information | protein:ligand interactions and conformational changes by molecular dynamics and Monte Carlo simulations, overview | Saccharolobus solfataricus |
physiological function | archaeal initiation factor 2 is a protein involved in the initiation of protein biosynthesis. In its GTP-bound, ON conformation, aIF2 binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, OFF conformation, it dissociates from tRNA, molecular dynamics, overview. AIF2 is largely responsible for recruiting the first, initiator tRNA to the ribosome and positioning it correctly, in register with the start codon of the ribosome-bound mRNA | Saccharolobus solfataricus |