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Literature summary for 3.6.4.6 extracted from

  • Legent, K.; Liu, H.H.; Treisman, J.E.
    Drosophila Vps4 promotes epidermal growth factor receptor signaling independently of its role in receptor degradation (2015), Development, 142, 1480-1491.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.6

Protein Variants

Protein Variants Comment Organism
E209K site-directed mutagenesis Drosophila melanogaster
additional information construction of Vps4 knockout mutants, loss of Vps4 affects multiple signaling pathways, phenotypes, detailed overview Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Drosophila melanogaster 16020
-
vesicle intra-lumenal Drosophila melanogaster 31982
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Drosophila melanogaster
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9Y162
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Drosophila melanogaster
-
ovary follicle cell Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Drosophila melanogaster ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
hexamer
-
 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
vacuolar protein sorting 4
-
 Drosophila melanogaster
Vps4
-
 Drosophila melanogaster

General Information

General Information Comment Organism
evolution enzyme vacuolar protein sorting 4, Vps4, belongs to the AAA ATPases. Vps4 forms a hexameric complex that disassembles ESCRT-III, allowing recycling of its components, and also plays an active role in scission of the vesicle neck. Vps4 is required for epidermal growth factor receptor signaling even in the absence of Shibire, the Dynamin that internalizes epidermal growth factor receptor from the plasma membrane. In ovarian follicle cells, in contrast, Vps4 does not affect epidermal growth factor receptor signaling, although it is still essential for receptor degradation, Vps4 is not required for EGFR or Notch signaling in follicle cells. Enzyme Vps4 can promote epidermal growth factor receptor activity through an endocytosis-independent mechanism, a non-endocytic and cell type-dependent mechanism. Protein Vps4 is the only energy-utilizing ESCRT component Drosophila melanogaster
malfunction photoreceptors are largely absent from Vps4 mutant clones in the eye disc, the resulting mutant R8 photoreceptors fail to recruit surrounding cells to differentiate as R1-R7 photoreceptors. Loss of Vps4 disrupts the epidermal growth factor receptor, EGFR, pathway. In imaginal disc cells deficient for enzyme Vps4, EGFR and other receptors accumulate in endosomes, and EGFR target genes are not expressed Drosophila melanogaster
physiological function enzyme vacuolar protein sorting 4, Vps4, interacts with the endosomal sorting complexes required for transport, ESCRT-III, complex to drive the final step of intra-lumenal vesicles formation Drosophila melanogaster