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Literature summary for 3.6.1.75 extracted from
- Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DGPP (2000), J. Biol. Chem., 275, 40887-40896.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inositol induces the enzyme in both exponential and stationary phase cells | Saccharomyces cerevisiae |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression from a plasmid vector bearing the PDPP1-lacZ reporter gene, expression analysis in presence or absence of inositol | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDP | - |
Saccharomyces cerevisiae |  |
| CDP-diacylglycerol | mixed inhibition mechanism | Saccharomyces cerevisiae | |
| additional information | no or poor inhibition by phospholipids, overview | Saccharomyces cerevisiae |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
x * 34000, SDS-PAGE | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | DGPP phosphatase plays a role in the regulation of phospholipid metabolism by inositol, as well as regulating the cellular levels of phosphatidylinositol, regulation of DGPP phosphatase by inositol and growth phase, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | DGPP phosphatase plays a role in the regulation of phospholipid metabolism by inositol, as well as regulating the cellular levels of phosphatidylinositol, regulation of DGPP phosphatase by inositol and growth phase, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | DGPP stimulates the activity of pure phosphatidylserine synthase by a mechanism that increases the affinity of the enzyme for its substrate CDP-diacylglycerol | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 34000, SDS-PAGE | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DGPP phosphatase | - |
Saccharomyces cerevisiae |
| diacylglycerol pyrophosphate phosphatase | - |
Saccharomyces cerevisiae |
| DPP1-encoded diacylglycerol pyrophosphate phosphatase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
assay at | Saccharomyces cerevisiae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | value for CDP-diacylglacerol is 5 mol% | Saccharomyces cerevisiae |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 2.6 | - |
- |
Saccharomyces cerevisiae | CDP | |
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Release 2023.1 (January 2023)
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