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Literature summary for 3.6.1.71 extracted from

  • Marriott, A.S.; Copeland, N.A.; Cunningham, R.; Wilkinson, M.C.; McLennan, A.G.; Jones, N.J.
    Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication (2015), DNA Repair, 33, 90-100 .
    View publication on PubMed
Search for more literature for 3.6.1.71

Organism

Organism UniProt Comment Textmining
Cricetulus griseus G3I8V7
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Homo sapiens Q7Z2E3
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Source Tissue

Source Tissue Comment Organism Textmining
CHO-AA8 cell
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 Cricetulus griseus
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CHO-EM9 cell
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 Cricetulus griseus
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FD105 cell FD105-M20 cell Homo sapiens
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FD105 cell FD105-M21 cell Homo sapiens
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HeLa cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
I79_019989
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 Cricetulus griseus

General Information

General Information Comment Organism
physiological function FD105 cells, lacking aprataxin, show a 5.7-fold increase in diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) level Homo sapiens
physiological function knockdown of aprataxin expression in EM-9 cells leads to an 8fold increase in Ap4A level to 31.4 pmol/106 cells. APTX knockdown greatly enhances the mitomycin C-induced Ap4A increase in AA-8 cells from 3.9 to 10.6 pmol/106 cells Cricetulus griseus