Literature summary for 3.6.1.70 extracted from

Raponi, M.; Lancet, J.E.; Fan, H.; Dossey, L.; Lee, G.; Gojo, I.; Feldman, E.J.; Gotlib, J.; Morris, L.E.; Greenberg, P.L.; Wright, J.J.; Harousseau, J.L.; Loewenberg, B.; Stone, R.M.; De Porre, P.; Wang, Y.; Karp, J.E.
A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia (2008), Blood, 111, 2589-2596 .

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Application

Application	Comment	Organism
medicine	in bone marrow of patients from a phase 2 study of the farnesyltransferase inhibitor tipifarnib in older adults with previously untreated acute myeloid leukemia, te RASGRP1/APTX gene expression ratio predicts response to tipifarnib with the greatest accuracy. RASGRP1 is a guanine nucleotide exchange factor that activates RAS, while APTX (aprataxin) is involved in DNA excision repair	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q7Z2E3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
aprataxin	-	Homo sapiens
APTX	-	Homo sapiens

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Release 2023.1 (January 2023)