Literature summary for 3.6.1.59 extracted from

Singh, J.; Salcius, M.; Liu, S.W.; Staker, B.L.; Mishra, R.; Thurmond, J.; Michaud, G.; Mattoon, D.R.; Printen, J.; Christensen, J.; Bjornsson, J.M.; Pollok, B.A.; Kiledjian, M.; Stewart, L.; Jarecki, J.; Gurney, M.E.
DcpS as a therapeutic target for spinal muscular atrophy (2008), ACS Chem. Biol., 3, 711-722.

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Application

Application	Comment	Organism
medicine	identification of DcpS as a candidate molecular target of the C5-substituted quinazolines for the potential treatment of spinal muscular atrophy	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
C5-substituted quinazolines	C5-quinazolines potently inhibit DcpS decapping activity. Binding of C5-substituted quinazolines to DcpS holds the enzyme in an open, catalytically incompetent conformation	Homo sapiens
D156844	highly effective at inhibiting recombinant DcpS decapping activity	Homo sapiens
m7G5'ppp5'G	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	DcpS is a nuclear shuttling protein	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
m7G5'ppp5'N(3'ppp5'N)n + H2O	Homo sapiens	n = 1-8	7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96C86	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
m7G5'ppp5'N(3'ppp5'N)n + H2O	n = 1-8	Homo sapiens	7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n	-	?

Synonyms

Synonyms	Comment	Organism
Dcps	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000015	-	pH and temperature not specified in the publication	Homo sapiens	D156844
0.00003	-	pH and temperature not specified in the publication	Homo sapiens	m7G5'ppp5'G

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Release 2023.1 (January 2023)