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Literature summary for 3.6.1.39 extracted from

  • Dunham, L.F.; Price, A.R.
    Deoxythymidine triphosphate-deoxyuridine triphosphate nucleotidohydrolase induced by Bacillus subtilis bacteriophage phie (1974), Biochemistry, 13, 2667-2672.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
sulfhydryl compound required for activity of the partially purified enzyme Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
diphosphate with dTTP or dUDP as substrate Bacillus subtilis
dTDP with dTTP or dUTP as substrate Bacillus subtilis
dUDP with dTTP or dUTP as substrate Bacillus subtilis
dUTP with dTTP as substrate Bacillus subtilis
EDTA complete inhibition Bacillus subtilis
additional information different purin- and pyrimidinnucleotide tested Bacillus subtilis
para-hydroxy-mercuribenzoate no inhibition in presence of 25 mM beta-mercaptoethanol Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
dUTP
-
Bacillus subtilis
0.4
-
dTTP
-
Bacillus subtilis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated Bacillus subtilis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ weak activator Bacillus subtilis
Ca2+ weak activator Bacillus subtilis
K+ weak activator Bacillus subtilis
Li+ weak activator Bacillus subtilis
Mg2+ 50 mM MgCl2, maximum activity Bacillus subtilis
Mn2+
-
Bacillus subtilis
Na+ weak activator Bacillus subtilis
Zn2+ effective activator Bacillus subtilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
gel filtration in presence of 1% Triton Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTTP + H2O Bacillus subtilis
-
dTDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
infected with phage phi
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTTP + H2O
-
Bacillus subtilis dTMP + diphosphate
-
?
dTTP + H2O
-
Bacillus subtilis dTDP + phosphate
-
?
dUTP + H2O
-
Bacillus subtilis dUMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
dTTPase-dUTPase
-
-

pH Range

pH Minimum pH Maximum Comment Organism
7 10.5
-
Bacillus subtilis