Activating Compound | Comment | Organism | Structure |
---|---|---|---|
PCMB | inhibits at high concentrations, activates at low concentrations | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | - |
Homo sapiens | |
cysteine | - |
Homo sapiens | |
diphosphate | - |
Homo sapiens | |
EDTA | - |
Homo sapiens | |
PCMB | inhibits at high concentrations, activates at low concentrations | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
D-glucosamine 6-phosphate | pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+ | Homo sapiens | |
2.37 | - |
D-glucosamine 6-phosphate | pH 8.5, 37°C, without activator | Homo sapiens | |
3.5 | - |
D-fructose 6-phosphate | pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+ | Homo sapiens | |
16 | - |
NH4+ | pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+ | Homo sapiens | |
22.5 | - |
D-fructose 6-phosphate | pH 8.5, 37°C, in absence of activators | Homo sapiens | |
25 | - |
NH4+ | in absence of activators | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | activates | Homo sapiens | |
Hg2+ | activates | Homo sapiens | |
Mg2+ | activates | Homo sapiens | |
Mn2+ | activates, reverses inhibition by EDTA | Homo sapiens | |
additional information | Mn2+, Hg2+, Mg2+, Co2+ and Ni2+ enhance in decreasing order the activity in both directions | Homo sapiens | |
Ni2+ | activates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucosamine 6-phosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + NH3 | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | 8.7 | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9.5 | pH 7.0: about 55% of maximal activity, pH 9.5: about 74% of maximal activity | Homo sapiens |