Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the virion infectivity factor of HIV binds cytoplasmic enzyme marking it for degradation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxycytosine in single-stranded viral DNA + H2O | Homo sapiens | - |
deoxyuridine in single-stranded viral DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HC16 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture condition:CD4+ cell | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxycytosine in single-stranded viral DNA + H2O | - |
Homo sapiens | deoxyuridine in single-stranded viral DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A3G | - |
Homo sapiens |
APOBEC3G | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine to deoxyuridine in signature trinucleotides (CCC, TCC) on minus strand viral DNA during reverse transcription. The enzyme restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. The enzyme contributes to the evasion of adaptive immunity by HIV | Homo sapiens |