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Literature summary for 3.5.4.6 extracted from
- Divergent N-terminal regions in AMP deaminase and isoform-specific catalytic properties of the enzymes (1995), Arch. Biochem. Biophys., 321, 372-380.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | activates | Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.6 | 0.8 | AMP | AMPD1, endogenous, with 12.5 mM ATP | Homo sapiens | |
| 0.6 | 1 | AMP | AMPD1, endogenous, without ATP | Homo sapiens | |
| 1.1 | 2.2 | AMP | AMPD2, endogenous, with 12.5 mM ATP | Homo sapiens | |
| 1.4 | - |
AMP | recombinant AMPD1, with 12.5 mM ATP | Homo sapiens | |
| 3.2 | - |
AMP | recombinant AMPD1, without ATP | Homo sapiens | |
| 3.5 | - |
AMP | recombinant AMPD2, with 12.5 mM ATP | Homo sapiens | |
| 4.5 | 9.9 | AMP | AMPD2, endogenous, without ATP | Homo sapiens | |
| 11.5 | - |
AMP | recombinant AMPD2, without ATP | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
AMPD1, AMPD2 and AMPD3 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + H2O | - |
Homo sapiens | IMP + NH3 | - |
ir | |
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