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Literature summary for 3.5.3.25 extracted from

  • Kumagai, T.; Koyama, Y.; Oda, K.; Noda, M.; Matoba, Y.; Sugiyama, M.
    Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae (2010), Antimicrob. Agents Chemother., 54, 1132-1139.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.25

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces lavendulae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Nomega-hydroxy-L-arginine + H2O Streptomyces lavendulae the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species L-ornithine + hydroxyurea
-
 ?
Nomega-hydroxy-L-arginine + H2O Streptomyces lavendulae ATCC 11924 the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species L-ornithine + hydroxyurea
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces lavendulae D2Z025
-
-
Streptomyces lavendulae ATCC 11924 D2Z025
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptomyces lavendulae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nomega-hydroxy-L-arginine + H2O the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae L-ornithine + hydroxyurea
-
 ?
Nomega-hydroxy-L-arginine + H2O L-arginine is not a substrate Streptomyces lavendulae L-ornithine + hydroxyurea
-
 ?
Nomega-hydroxy-L-arginine + H2O the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae ATCC 11924 L-ornithine + hydroxyurea
-
 ?
Nomega-hydroxy-L-arginine + H2O L-arginine is not a substrate Streptomyces lavendulae ATCC 11924 L-ornithine + hydroxyurea
-
 ?

Synonyms

Synonyms Comment Organism
DcsB
-
 Streptomyces lavendulae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptomyces lavendulae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Streptomyces lavendulae

General Information

General Information Comment Organism
physiological function the enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species Streptomyces lavendulae