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Literature summary for 3.5.3.18 extracted from
- Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine (2015), Biochem. Biophys. Res. Commun., 458, 869-876 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in patients with type 2 diabetes mellitus, the percentage of senescent endothelial progenitor cells increases while the expression of DDAH2 decreases concomitantly with an increase in the plasma levels of asymmetric dimethylarginine. Exogenous application of asymmetric dimethylarginine accelerates the senescence of cultured endothelial progenitor cells in a dose-dependent manner, and overexpression of DDAH2 inhibits high glucose-induced endothelial progenitor cells senescence. Resveratrol (activating silent information regulator SIRT1) inhibits high glucose-induced endothelial progenitor cells senescence by upregulating the expression of DDAH2 and decreasing the levels of asymmetric dimethylarginine | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O95865 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDAH2 | - |
Homo sapiens |
| dimethylaminohydrolase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | resveratrol activates silent information regulator SIRT1 and inhibits upregulates the expression of DDAH2 | up |
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