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Literature summary for 3.5.2.2 extracted from
- Amidohydrolases of the reductive pyrimidine catabolic pathway: Purification, characterization, structure, reaction mechanisms and enzyme deficiency (2008), Biochim. Biophys. Acta, 1784, 431-444.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R412M | inactive | Homo sapiens |
| W360R | inactive | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc-metalloenzyme | Homo sapiens |  |
| Zn2+ | zinc-metalloenzyme | Rattus norvegicus | |
| Zn2+ | zinc-metalloenzyme | Bos taurus | |
| Zn2+ | zinc-metalloenzyme | Dictyostelium discoideum | |
| Zn2+ | zinc-metalloenzyme | Lachancea kluyveri | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Dictyostelium discoideum | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Lachancea kluyveri | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Dictyostelium discoideum | - |
| liver | - |
Lachancea kluyveri | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrothymine + H2O | - |
Homo sapiens | ? | - |
? | |
| 5,6-dihydrothymine + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 5,6-dihydrothymine + H2O | - |
Bos taurus | ? | - |
? | |
| 5,6-dihydrothymine + H2O | - |
Dictyostelium discoideum | ? | - |
? | |
| 5,6-dihydrothymine + H2O | - |
Lachancea kluyveri | ? | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Homo sapiens | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Rattus norvegicus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Dictyostelium discoideum | 3-ureidopropionate | - |
? | |
| 5,6-dihydrouracil + H2O | - |
Lachancea kluyveri | 3-ureidopropionate | - |
? | |
| additional information | does not hydrolyze hydantoins | Dictyostelium discoideum | ? | - |
? | |
| additional information | does not hydrolyze hydantoins | Lachancea kluyveri | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Homo sapiens |
| homotetramer | - |
Rattus norvegicus |
| homotetramer | - |
Bos taurus |
| homotetramer | - |
Dictyostelium discoideum |
| homotetramer | - |
Lachancea kluyveri |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHPase | - |
Homo sapiens |
| DHPase | - |
Rattus norvegicus |
| DHPase | - |
Bos taurus |
| DHPase | - |
Dictyostelium discoideum |
| DHPase | - |
Lachancea kluyveri |
| dihydropyrimidine amidohydrolase | - |
Homo sapiens |
| dihydropyrimidine amidohydrolase | - |
Rattus norvegicus |
| dihydropyrimidine amidohydrolase | - |
Bos taurus |
| dihydropyrimidine amidohydrolase | - |
Dictyostelium discoideum |
| dihydropyrimidine amidohydrolase | - |
Lachancea kluyveri |
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