Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MS-275 | - |
Homo sapiens | |
scriptaid | - |
Homo sapiens | |
suberoylanilide hydroxamic acid | - |
Homo sapiens | |
trichostatin A | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
airway epithelial cell | - |
Homo sapiens | - |
primary cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HDAC7 | - |
Homo sapiens |
histone deacetylase 7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | HDAC inhibition improves DELTAF508 cystic fibrosis transmembrane conductance regulator stability and trafficking, silencing of HDAC2 and HDAC3 causes a 2.5fold and 1.5fold increase in DELTAF508 cystic fibrosis transmembrane conductance regulator mRNA, respectively, as well as an about 5fold increase in total DELTAF508 protein. Silencing of HDAC1 induces a 1.4fold stimulation of iodide efflux. In contrast, silencing of HDAC7 exhibits a 3.6fold stimulation of cAMP-mediated iodide efflux comparable to 30°C efflux | Homo sapiens |
physiological function | HDAC7 plays a central role in restoration of DELTAF508 cystic fibrosis transmembrane conductance regulator function | Homo sapiens |