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Literature summary for 3.5.1.88 extracted from

  • Vadivelu, A.; Gopal, V.; Uma Maheswara Reddy, C.
    Molecular docking studies of 1,3,4-thiadiazoles as novel peptide deformylase inhibitors as potential antibacterial agents (2015), Int. J. Pharm. Sci. Rev. Res., 31, 58-62 .
No PubMed abstract available
Search for more literature for 3.5.1.88

Inhibitors

Inhibitors Comment Organism Structure
(E)-1,5-dimethyl-2-phenyl-4-((5-styryl-1,3,4-thiadiazol-2-yl)amino-1,2-dihydro-3H-pyrazole-3-one)
-
 Escherichia coli
(E)-5-methyl-N-(5-styryl-1,3,4-thiadiazole-2-yl)isoxazol-3-amine
-
 Escherichia coli
(E)-5-styryl-N-(4H-1,2,4-triazol-4-yl)-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
(E)-N-(furan-2-ylmethyl)-5-styryl-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
(Z)-4-hydroxy-3-(5-((4-(phenyldiazenyl) phenyl) amino)-1,3,4-thiadiazol-2-yl)benzene sulfonic acid
-
 Escherichia coli
(Z)-5-(3,4-dimethoxyphenyl)-N-(4-(phenyl diazenyl) phenyl)-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
(Z)-N-(4-methylpyridine-2-yl)-5-styryl-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
3-(5-((4H-1,2,4-triazol-4-yl)amino)-1,3,4-thiadiazol-2-yl)-4-hydroxy benzenesulfonic acid
-
 Escherichia coli
3-(5-((furan-2-ylmethyl)amino)-1,3,4-thiadiazole-2-yl)-4-hydroxybenzenesulfonic acid
-
 Escherichia coli
3-(5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-4H-1,2,4-triazol-3-yl)-4-hydroxybenzenesulfonic acid
-
 Escherichia coli
4-((5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
-
 Escherichia coli
4-hydroxy-3-(5-((5-methylisoxazol-3-yl)amino)-1,3,4-thiadiazol-2-yl)benzenesulfonic acid
-
 Escherichia coli
4-hydroxy-3-(5-[(4-methylpyridin-2-yl)amino]-4H-1,2,4-triazol-3-yl)benzenesulfonic acid
-
 Escherichia coli
5-(3,4-dimethoxyphenyl)-N-(4-methylpyridine-2-yl)-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
5-(3,4-dimethoxyphenyl)-N-(4H-1,2,4-triazol-4-yl)-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
5-(3,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
additional information molecular docking studies of 1,3,4-thiadiazoles as peptide deformylase inhibitors, molecular modeling of the enzyme binding mode, docking study using the structure of Escherichia coli enzyme (PDB ID 1G27) complexed with inhibitor Bb-3497, overview. The compounds are potential antibacterial agents. Enzyme binding involves residues Gly45, Gly89, Glu95, Cys90, Leu91, Leu46, Met 38, Ile44, and Ile128 Escherichia coli
N-(4-((Z)-phenyldiazenyl) phenyl)-5-((Z)-styryl)-1,3,4-thiadiazol-2-amine
-
 Escherichia coli
N-(5-(3,4-dimethoxy phenyl)-1,3,4-thiadiazol-2-yl)-5-methylisoxazol-3-amine
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli ATCC 11775
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-
-

Synonyms

Synonyms Comment Organism
PDF
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0165
-
 pH and temperature not specified in the publication Escherichia coli N-(4-((Z)-phenyldiazenyl) phenyl)-5-((Z)-styryl)-1,3,4-thiadiazol-2-amine
0.0224
-
 pH and temperature not specified in the publication Escherichia coli (E)-5-styryl-N-(4H-1,2,4-triazol-4-yl)-1,3,4-thiadiazol-2-amine
0.0259
-
 pH and temperature not specified in the publication Escherichia coli (E)-1,5-dimethyl-2-phenyl-4-((5-styryl-1,3,4-thiadiazol-2-yl)amino-1,2-dihydro-3H-pyrazole-3-one)
0.0277
-
 pH and temperature not specified in the publication Escherichia coli (Z)-N-(4-methylpyridine-2-yl)-5-styryl-1,3,4-thiadiazol-2-amine
0.0284
-
 pH and temperature not specified in the publication Escherichia coli (E)-5-methyl-N-(5-styryl-1,3,4-thiadiazole-2-yl)isoxazol-3-amine
0.0652
-
 pH and temperature not specified in the publication Escherichia coli (E)-N-(furan-2-ylmethyl)-5-styryl-1,3,4-thiadiazol-2-amine
0.0915
-
 pH and temperature not specified in the publication Escherichia coli N-(5-(3,4-dimethoxy phenyl)-1,3,4-thiadiazol-2-yl)-5-methylisoxazol-3-amine
0.0972
-
 pH and temperature not specified in the publication Escherichia coli 5-(3,4-dimethoxyphenyl)-N-(4H-1,2,4-triazol-4-yl)-1,3,4-thiadiazol-2-amine
0.0995
-
 pH and temperature not specified in the publication Escherichia coli 3-(5-((4H-1,2,4-triazol-4-yl)amino)-1,3,4-thiadiazol-2-yl)-4-hydroxy benzenesulfonic acid
0.1035
-
 pH and temperature not specified in the publication Escherichia coli 4-hydroxy-3-(5-((5-methylisoxazol-3-yl)amino)-1,3,4-thiadiazol-2-yl)benzenesulfonic acid
0.1279
-
 pH and temperature not specified in the publication Escherichia coli 4-hydroxy-3-(5-[(4-methylpyridin-2-yl)amino]-4H-1,2,4-triazol-3-yl)benzenesulfonic acid
0.1725
-
 pH and temperature not specified in the publication Escherichia coli 5-(3,4-dimethoxyphenyl)-N-(4-methylpyridine-2-yl)-1,3,4-thiadiazol-2-amine
0.2061
-
 pH and temperature not specified in the publication Escherichia coli (Z)-5-(3,4-dimethoxyphenyl)-N-(4-(phenyl diazenyl) phenyl)-1,3,4-thiadiazol-2-amine
0.2743
-
 pH and temperature not specified in the publication Escherichia coli 5-(3,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)-1,3,4-thiadiazol-2-amine
0.2753
-
 pH and temperature not specified in the publication Escherichia coli 3-(5-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-4H-1,2,4-triazol-3-yl)-4-hydroxybenzenesulfonic acid
0.3043
-
 pH and temperature not specified in the publication Escherichia coli 4-((5-(3,4-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
0.323
-
 pH and temperature not specified in the publication Escherichia coli (Z)-4-hydroxy-3-(5-((4-(phenyldiazenyl) phenyl) amino)-1,3,4-thiadiazol-2-yl)benzene sulfonic acid
0.4819
-
 pH and temperature not specified in the publication Escherichia coli 3-(5-((furan-2-ylmethyl)amino)-1,3,4-thiadiazole-2-yl)-4-hydroxybenzenesulfonic acid