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Literature summary for 3.5.1.88 extracted from

  • Khan, F.A.K.; Jadhav, K.S.; Patil, R.H.; Shinde, D.B.; Arote, R.B.; Sangshetti, J.N.
    Biphenyl tetrazole-thiazolidinediones as novel bacterial peptide deformylase inhibitors synthesis, biological evaluations and molecular docking study (2016), Biomed. Pharmacother., 83, 1146-1153 .
    View publication on PubMed
Search for more literature for 3.5.1.88

Cloned(Commentary)

Cloned (Comment) Organism
enzyme from Escherichia coli strain NCIM 2931 Escherichia coli

General Stability

General Stability Organism
Ni2+ activates and stabilizes at 5 mM Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(5Z)-5-([2-[(E)-2-(dimethylamino)ethenesulfonyl]-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-5-yl]methylidene)-1,3-thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2,4-dimethoxybenzylidene) thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2,5-dimethoxybenzylidene) thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2,6-dichlorobenzylidene) thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(3,4,5-trimethoxybenzylidene) thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(3,4-dimethoxybenzylidene) thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(4-chlorobenzylidene)thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(4-methoxybenzylidene) thiazolidine-2,4-dione
-
 Escherichia coli
(E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-benzylidenethiazolidine-2,4-dione
-
 Escherichia coli
4-[(Z)-[3-(2-chlorobenzoyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]-N-(4-phenyl-1,3-thiazol-2-yl)benzene-1-sulfonamide
-
 Escherichia coli
5-bromo-7-methyl-2-propyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3H-imidazo[4,5-b]pyridine
-
 Escherichia coli
6-chloro-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole
-
 Escherichia coli
additional information biphenyl tetrazole-thiazolidinediones as bacterial peptide deformylase inhibitors: synthesis, biological evaluations, and molecular docking study, overview. MIC values with Escherichia coli and Bacillus subtilis cells Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ activates, stabilizes at 5 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6K3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-formyl-Met-Ala + H2O
-
 Escherichia coli formate + Met-Ala
-
 ?

Synonyms

Synonyms Comment Organism
PDF
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0039
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli 6-chloro-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole
0.0162
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli 5-bromo-7-methyl-2-propyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3H-imidazo[4,5-b]pyridine
0.01625
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(4-chlorobenzylidene)thiazolidine-2,4-dione
0.01725
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2,6-dichlorobenzylidene) thiazolidine-2,4-dione
0.018
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione
0.0205
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-benzylidenethiazolidine-2,4-dione
0.026
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(4-methoxybenzylidene) thiazolidine-2,4-dione
0.02625
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione
0.0265
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2,5-dimethoxybenzylidene) thiazolidine-2,4-dione
0.02675
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(3,4-dimethoxybenzylidene) thiazolidine-2,4-dione
0.033
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(3,4,5-trimethoxybenzylidene) thiazolidine-2,4-dione
0.0355
-
 pH 7.4, 30°C, recombinant enzyme Escherichia coli (E)-3-((20-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-5-(2,4-dimethoxybenzylidene) thiazolidine-2,4-dione