BRENDA - Enzyme Database
show all sequences of 3.5.1.88

Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents

Jain, R.; Chen, D.; White, R.J.; Patel, D.V.; Yuan, Z.; Curr. Med. Chem. 12, 1607-1621 (2005)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
target for the development of new antibacterial drugs
Haemophilus influenzae
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-oxo-pyrrolidine with chelators
-
Haemophilus influenzae
2-thioxo-4-thiazolidinone N-hexanoic acid
IC50 against Escherichia coli peptide deformylase: 0.00166 mM
Haemophilus influenzae
actinonin
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM
Haemophilus influenzae
aldehyde peptide
IC50 against Escherichia coli peptide deformylase: 0.01 mM
Haemophilus influenzae
alkyl-succinate-proline hydroxamate
IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM
Haemophilus influenzae
benzimidazole N-formyl hydroxylamine
-
Haemophilus influenzae
benzothiazinone derivatives
IC50: 0.000005 mM
Haemophilus influenzae
benzothiazolylidene hydroxamic acid derivatives
IC50 against Escherichia coli peptide deformylase: 0.00104 mM
Haemophilus influenzae
beta-sulfonylhydroxamic acid
IC50 against Escherichia coli peptide deformylase: 0.000016 mM
Haemophilus influenzae
carbamate N-formyl hydroxylamine
-
Haemophilus influenzae
heteroarylaryl(P2'/P3')N-formyl hydroxylamine
-
Haemophilus influenzae
hydantoin
IC50 against Escherichia coli peptide deformylase: 0.0002 mM
Haemophilus influenzae
hydrazide N-formyl hydroxylamine
-
Haemophilus influenzae
isoxazole-3-hydroxamic acid derivatives
IC50 against Escherichia coli peptide deformylase: 0.0034 mM
Haemophilus influenzae
N-alkyl urea hydroxamate
IC50 against Escherichia coli peptide deformylase: 0.000003 mM
Haemophilus influenzae
N-hydroxy urea
IC50 against Escherichia coli peptide deformylase: 0.0022 mM
Haemophilus influenzae
N-hydroxy-2-(substituted phenyl) acetamide
-
Haemophilus influenzae
N-hydroxy-N-(3-hydrazino-3-oxopropyl)formamide
-
Haemophilus influenzae
N-substituted methionine hydrazide
IC50 against Escherichia coli peptide deformylase: 0.2 mM
Haemophilus influenzae
N-sulfonyl-L-Val-L-Leu-hydroxamate
-
Haemophilus influenzae
pseudopeptide metabolites
IC50 against Escherichia coli peptide deformylase: 0.000030 mM
Haemophilus influenzae
pyrrolidine bicyclic(P2'/P3')compounds
-
Haemophilus influenzae
quinazoline hydroxamic acid
IC50 against Escherichia coli peptide deformylase: 0.00012 mM
Haemophilus influenzae
thio peptide
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif
Haemophilus influenzae
thiol peptide
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified
Haemophilus influenzae
thyropropic acid derivatives
IC50 against Escherichia coli peptide deformylase: 0.001 mM
Haemophilus influenzae
urea analogs(P2'/P3')of N-formyl hydroxylamine
-
Haemophilus influenzae
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
-
Haemophilus influenzae
Ni2+
-
Haemophilus influenzae
Zn2+
-
Haemophilus influenzae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
formyl-L-methionyl peptide + H2O
Haemophilus influenzae
-
formate + methionyl peptide
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Haemophilus influenzae
-
-
-
Oxidation Stability
Oxidation Stability
Organism
ferrous ion in peptide deformylase is very unstable and is quickly and irreversibly oxidized to the ferric ion under laboratory conditions, resulting in an inactive enzyme.
Haemophilus influenzae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
formyl-L-methionyl peptide + H2O
-
673200
Haemophilus influenzae
formate + methionyl peptide
-
-
-
?
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0000003
-
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM
Haemophilus influenzae
actinonin
0.000003
-
IC50 against Escherichia coli peptide deformylase: 0.000003 mM
Haemophilus influenzae
N-alkyl urea hydroxamate
0.000004
0.00001
IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM
Haemophilus influenzae
alkyl-succinate-proline hydroxamate
0.000005
-
IC50: 0.000005 mM
Haemophilus influenzae
benzothiazinone derivatives
0.000016
-
IC50 against Escherichia coli peptide deformylase: 0.000016 mM
Haemophilus influenzae
beta-sulfonylhydroxamic acid
0.000019
-
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif
Haemophilus influenzae
thio peptide
0.00003
-
IC50 against Escherichia coli peptide deformylase: 0.000030 mM
Haemophilus influenzae
pseudopeptide metabolites
0.00012
-
IC50 against Escherichia coli peptide deformylase: 0.00012 mM
Haemophilus influenzae
quinazoline hydroxamic acid
0.0002
-
IC50 against Escherichia coli peptide deformylase: 0.0002 mM
Haemophilus influenzae
hydantoin
0.001
-
IC50 against Escherichia coli peptide deformylase: 0.001 mM
Haemophilus influenzae
thyropropic acid derivatives
0.00104
-
IC50 against Escherichia coli peptide deformylase: 0.00104 mM
Haemophilus influenzae
benzothiazolylidene hydroxamic acid derivatives
0.00166
-
IC50 against Escherichia coli peptide deformylase: 0.00166 mM
Haemophilus influenzae
2-thioxo-4-thiazolidinone N-hexanoic acid
0.0022
-
IC50 against Escherichia coli peptide deformylase: 0.0022 mM
Haemophilus influenzae
N-hydroxy urea
0.0025
-
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified
Haemophilus influenzae
thiol peptide
0.0034
-
IC50 against Escherichia coli peptide deformylase: 0.0034 mM
Haemophilus influenzae
isoxazole-3-hydroxamic acid derivatives
0.01
-
IC50 against Escherichia coli peptide deformylase: 0.01 mM
Haemophilus influenzae
aldehyde peptide
0.2
-
IC50 against Escherichia coli peptide deformylase: 0.2 mM
Haemophilus influenzae
N-substituted methionine hydrazide
Application (protein specific)
Application
Commentary
Organism
medicine
target for the development of new antibacterial drugs
Haemophilus influenzae
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0000003
-
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM
Haemophilus influenzae
actinonin
0.000003
-
IC50 against Escherichia coli peptide deformylase: 0.000003 mM
Haemophilus influenzae
N-alkyl urea hydroxamate
0.000004
0.00001
IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM
Haemophilus influenzae
alkyl-succinate-proline hydroxamate
0.000005
-
IC50: 0.000005 mM
Haemophilus influenzae
benzothiazinone derivatives
0.000016
-
IC50 against Escherichia coli peptide deformylase: 0.000016 mM
Haemophilus influenzae
beta-sulfonylhydroxamic acid
0.000019
-
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif
Haemophilus influenzae
thio peptide
0.00003
-
IC50 against Escherichia coli peptide deformylase: 0.000030 mM
Haemophilus influenzae
pseudopeptide metabolites
0.00012
-
IC50 against Escherichia coli peptide deformylase: 0.00012 mM
Haemophilus influenzae
quinazoline hydroxamic acid
0.0002
-
IC50 against Escherichia coli peptide deformylase: 0.0002 mM
Haemophilus influenzae
hydantoin
0.001
-
IC50 against Escherichia coli peptide deformylase: 0.001 mM
Haemophilus influenzae
thyropropic acid derivatives
0.00104
-
IC50 against Escherichia coli peptide deformylase: 0.00104 mM
Haemophilus influenzae
benzothiazolylidene hydroxamic acid derivatives
0.00166
-
IC50 against Escherichia coli peptide deformylase: 0.00166 mM
Haemophilus influenzae
2-thioxo-4-thiazolidinone N-hexanoic acid
0.0022
-
IC50 against Escherichia coli peptide deformylase: 0.0022 mM
Haemophilus influenzae
N-hydroxy urea
0.0025
-
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified
Haemophilus influenzae
thiol peptide
0.0034
-
IC50 against Escherichia coli peptide deformylase: 0.0034 mM
Haemophilus influenzae
isoxazole-3-hydroxamic acid derivatives
0.01
-
IC50 against Escherichia coli peptide deformylase: 0.01 mM
Haemophilus influenzae
aldehyde peptide
0.2
-
IC50 against Escherichia coli peptide deformylase: 0.2 mM
Haemophilus influenzae
N-substituted methionine hydrazide
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-oxo-pyrrolidine with chelators
-
Haemophilus influenzae
2-thioxo-4-thiazolidinone N-hexanoic acid
IC50 against Escherichia coli peptide deformylase: 0.00166 mM
Haemophilus influenzae
actinonin
IC50 against Escherichia coli peptide deformylase: 0.0000003 mM
Haemophilus influenzae
aldehyde peptide
IC50 against Escherichia coli peptide deformylase: 0.01 mM
Haemophilus influenzae
alkyl-succinate-proline hydroxamate
IC50 against Escherichia coli peptide deformylase: 0.000004-0.000010 mM
Haemophilus influenzae
benzimidazole N-formyl hydroxylamine
-
Haemophilus influenzae
benzothiazinone derivatives
IC50: 0.000005 mM
Haemophilus influenzae
benzothiazolylidene hydroxamic acid derivatives
IC50 against Escherichia coli peptide deformylase: 0.00104 mM
Haemophilus influenzae
beta-sulfonylhydroxamic acid
IC50 against Escherichia coli peptide deformylase: 0.000016 mM
Haemophilus influenzae
carbamate N-formyl hydroxylamine
-
Haemophilus influenzae
heteroarylaryl(P2'/P3')N-formyl hydroxylamine
-
Haemophilus influenzae
hydantoin
IC50 against Escherichia coli peptide deformylase: 0.0002 mM
Haemophilus influenzae
hydrazide N-formyl hydroxylamine
-
Haemophilus influenzae
isoxazole-3-hydroxamic acid derivatives
IC50 against Escherichia coli peptide deformylase: 0.0034 mM
Haemophilus influenzae
N-alkyl urea hydroxamate
IC50 against Escherichia coli peptide deformylase: 0.000003 mM
Haemophilus influenzae
N-hydroxy urea
IC50 against Escherichia coli peptide deformylase: 0.0022 mM
Haemophilus influenzae
N-hydroxy-2-(substituted phenyl) acetamide
-
Haemophilus influenzae
N-hydroxy-N-(3-hydrazino-3-oxopropyl)formamide
-
Haemophilus influenzae
N-substituted methionine hydrazide
IC50 against Escherichia coli peptide deformylase: 0.2 mM
Haemophilus influenzae
N-sulfonyl-L-Val-L-Leu-hydroxamate
-
Haemophilus influenzae
pseudopeptide metabolites
IC50 against Escherichia coli peptide deformylase: 0.000030 mM
Haemophilus influenzae
pyrrolidine bicyclic(P2'/P3')compounds
-
Haemophilus influenzae
quinazoline hydroxamic acid
IC50 against Escherichia coli peptide deformylase: 0.00012 mM
Haemophilus influenzae
thio peptide
IC50 against Escherichia coli peptide deformylase: 0.000019 mM, thiol chelating group combined with the best substrate motif
Haemophilus influenzae
thiol peptide
IC50 against Escherichia coli peptide deformylase: 0.0025 mM, designed based on the best substrate identified
Haemophilus influenzae
thyropropic acid derivatives
IC50 against Escherichia coli peptide deformylase: 0.001 mM
Haemophilus influenzae
urea analogs(P2'/P3')of N-formyl hydroxylamine
-
Haemophilus influenzae
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
-
Haemophilus influenzae
Ni2+
-
Haemophilus influenzae
Zn2+
-
Haemophilus influenzae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
formyl-L-methionyl peptide + H2O
Haemophilus influenzae
-
formate + methionyl peptide
-
-
?
Oxidation Stability (protein specific)
Oxidation Stability
Organism
ferrous ion in peptide deformylase is very unstable and is quickly and irreversibly oxidized to the ferric ion under laboratory conditions, resulting in an inactive enzyme.
Haemophilus influenzae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
formyl-L-methionyl peptide + H2O
-
673200
Haemophilus influenzae
formate + methionyl peptide
-
-
-
?
Other publictions for EC 3.5.1.88
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733007
Fieulaine
Understanding the highly effic ...
Homo sapiens
Acta Crystallogr. Sect. D
70
242-252
2014
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-
1
1
3
-
1
-
1
1
2
-
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4
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1
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1
1
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1
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1
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1
3
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1
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1
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1
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1
1
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1
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-
3
3
-
-
-
733786
Yang
Synthesis, antibacterial activ ...
Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis
Eur. J. Med. Chem.
86
133-152
2014
-
-
-
-
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-
142
-
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4
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142
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734093
Kumar
Identification of crucial amin ...
Mycobacterium tuberculosis, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
J. Bacteriol.
196
90-99
2014
-
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2
-
8
-
8
4
-
2
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3
-
5
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2
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6
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2
-
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4
2
-
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10
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2
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8
-
10
8
-
4
-
2
-
3
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-
-
2
-
-
-
-
6
-
2
-
-
4
2
-
-
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2
2
-
4
4
733023
Tran
Expression, crystallization an ...
Campylobacter jejuni
Acta Crystallogr. Sect. F
69
1120-1122
2013
-
-
1
1
-
-
-
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4
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1
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1
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1
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1
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-
-
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733109
O'Dwyer
Comparative analysis of the an ...
Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Streptococcus pyogenes, Streptomyces pneumoniae
Antimicrob. Agents Chemother.
57
2333-2342
2013
-
-
-
-
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8
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11
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8
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733259
Cui
Caffeic acid phenethyl ester ( ...
Helicobacter pylori
Biochem. Biophys. Res. Commun.
435
289-294
2013
-
-
-
1
-
-
9
-
-
1
-
-
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4
-
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2
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1
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2
9
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1
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733571
Randhawa
Overexpression of peptide defo ...
Homo sapiens
BMC Cancer
13
321
2013
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1
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2
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1
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2
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17
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1
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1
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17
-
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1
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-
1
2
2
1
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-
734011
Frank
Structure and function of a cy ...
Arabidopsis thaliana, Synechococcus phage S-SSM7
ISME J.
7
1150-1160
2013
-
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2
2
-
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1
1
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8
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1
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1
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1
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1
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1
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3
3
-
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-
735214
Di Toma
Purification and use of E. col ...
Escherichia coli
Protein Expr. Purif.
89
73-79
2013
-
1
1
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1
-
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1
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1
3
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1
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3
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1
1
1
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1
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1
1
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1
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1
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1
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1
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3
-
1
1
1
-
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-
1
-
-
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-
1
1
-
-
-
718759
Pereira-Castro
Transcriptional regulation of ...
Homo sapiens
Biochem. Biophys. Res. Commun.
421
825-831
2012
-
-
1
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2
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1
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3
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1
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1
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1
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3
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1
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1
1
1
1
-
-
719067
Axten
Acylprolinamides: A new class ...
Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae
Bioorg. Med. Chem. Lett.
22
4028-4032
2012
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131
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3
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3
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120
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120
131
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3
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3
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720284
Ananthula
Insights from ligand and struc ...
Staphylococcus aureus
J. Mol. Model.
18
693-708
2012
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45
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1
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1
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21
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21
45
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1
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1
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1
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16
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1
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1
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1
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-
696765
Wang
Prediction of the binding mode ...
Geobacillus stearothermophilus
Biophys. Chem.
134
178-184
2008
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1
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2
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1
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1
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698792
Saxena
Three consecutive arginines ar ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Ra / ATCC 25177
J. Biol. Chem.
283
23754-23764
2008
-
1
1
-
10
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1
9
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2
1
2
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13
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1
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4
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1
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8
1
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1
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10
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1
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9
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2
1
2
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1
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4
-
1
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8
1
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699764
Dong
Origins of the different metal ...
Escherichia coli
J. Phys. Chem. B
112
10280-10290
2008
-
-
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1
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2
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3
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2
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-
700712
Moon
Rice peptide deformylase PDF1B ...
Oryza sativa
Plant Cell Physiol.
49
1536-1546
2008
-
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1
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3
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2
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5
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1
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1
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5
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2
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2
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684694
Nguyen
Zinc is the metal cofactor of ...
Borreliella burgdorferi
Arch. Biochem. Biophys.
468
217-225
2007
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1
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2
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1
2
1
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5
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1
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1
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2
1
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2
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1
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2
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1
2
1
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1
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1
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2
1
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687465
Park
Characterization of peptide de ...
Bacillus cereus
J. Biochem. Mol. Biol.
40
1050-1057
2007
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1
1
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3
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1
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1
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-
687836
Antczak
High-throughput identification ...
Homo sapiens
J. Biomol. Screen.
12
521-535
2007
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17
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2
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2
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16
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16
17
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1
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-
688243
Boularot
Discovery and refinement of a ...
Arabidopsis thaliana, Bacillus subtilis, Escherichia coli, Homo sapiens
J. Med. Chem.
50
10-20
2007
-
-
-
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41
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1
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7
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60
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-
74
63
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1
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-
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688615
Xiao
Catalytic mechanism and metal ...
Escherichia coli
J. Phys. Chem. B
111
6229-6235
2007
-
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2
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1
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-
688616
Wu
Theoretical study of the catal ...
Escherichia coli
J. Phys. Chem. B
111
6236-6244
2007
-
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1
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2
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1
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1
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-
-
-
-
-
-
-
689043
Bouzaidi-Tiali
Type 3 peptide deformylases ar ...
Trypanosoma brucei
Mol. Microbiol.
65
1218-1228
2007
-
-
-
-
-
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1
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2
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6
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2
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2
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689452
Hou
Plant peptide deformylase: a n ...
Arabidopsis sp.
Plant Biotechnol. J.
5
275-281
2007
-
2
1
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3
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4
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1
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3
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-
671914
Yuan
The evolution of peptide defor ...
Bacteria
Biochem. Pharmacol.
71
1042-1047
2006
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1
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1
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5
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-
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675609
Leopoldini
Role of the metal ion in formy ...
Escherichia coli
J. Phys. Chem. B
110
1063-1072
2006
-
1
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-
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-
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5
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1
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1
1
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1
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1
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5
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
677015
Cai
Peptide deformylase is a poten ...
Helicobacter pylori
Protein Sci.
15
2071-2081
2006
-
1
1
1
-
-
2
-
-
4
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1
-
4
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2
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1
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1
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2
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1
1
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1
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2
2
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4
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1
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2
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1
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-
1
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-
-
-
-
-
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-
-
687059
Chikhi
Theoretical study of Escherich ...
Escherichia coli
In Silico Biol.
6
459-466
2006
-
-
-
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1
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4
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687372
Huang
Phylogenomic and biochemical c ...
Legionella pneumophila, Legionella pneumophila Philadelphia 1
J. Bacteriol.
188
5249-5257
2006
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1
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2
17
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2
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5
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1
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6
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8
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1
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2
8
17
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2
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1
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-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671162
Park
Crystallization and preliminar ...
Bacillus cereus
Acta Crystallogr. Sect. F
61
150-152
2005
-
1
1
1
-
-
1
-
-
2
1
1
-
4
-
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1
-
-
-
-
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1
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-
-
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-
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1
1
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1
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1
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2
1
1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671700
Saxena
The carboxy-terminal end of th ...
Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
332
418-425
2005
-
-
1
-
4
-
2
1
-
2
1
1
-
5
-
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1
-
1
-
-
-
2
-
1
1
-
-
1
-
-
-
1
-
-
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1
-
-
4
-
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2
1
1
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2
1
1
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1
1
-
-
-
2
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
673200
Jain
Bacterial Peptide deformylase ...
Haemophilus influenzae
Curr. Med. Chem.
12
1607-1621
2005
-
1
-
-
-
-
27
-
-
3
-
1
-
1
1
-
-
-
-
-
-
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1
-
-
-
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-
-
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17
-
1
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-
17
27
-
-
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3
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1
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1
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-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674160
Chae
Peptide-cleaving catalyst sele ...
Escherichia coli
J. Am. Chem. Soc.
127
2396-2397
2005
-
1
-
-
-
-
1
-
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2
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1
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1
1
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-
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-
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1
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-
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1
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-
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1
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2
-
1
-
1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674257
Saxena
Identification of regions invo ...
Mycobacterium tuberculosis
J. Bacteriol.
187
8216-8220
2005
-
-
1
-
1
-
-
-
1
1
2
1
-
2
-
-
1
-
1
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
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1
1
2
1
-
-
-
1
1
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674518
Fieulaine
The crystal structure of mitoc ...
Arabidopsis thaliana
J. Biol. Chem.
280
42315-42324
2005
-
1
1
1
-
-
1
-
-
1
1
1
-
5
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
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1
1
-
1
-
-
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1
-
-
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1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674519
Zhou
Novel conformational states of ...
Leptospira interrogans
J. Biol. Chem.
280
42391-42396
2005
-
1
-
1
-
-
1
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
677041
Moon
Structure analysis of peptide ...
Bacillus cereus
Proteins
61
217-220
2005
-
1
-
1
-
-
1
-
-
2
-
1
-
2
-
-
-
-
-
-
-
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1
-
-
-
-
-
-
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-
-
-
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1
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-
1
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1
-
-
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2
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1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654102
Zhou
Co-crystallization of Leptospi ...
Leptospira interrogans
Acta Crystallogr. Sect. D
60
137-139
2004
-
-
-
1
-
-
1
-
-
-
-
-
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3
-
-
1
-
-
-
-
-
-
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-
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-
-
-
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654454
Han
Molecular cloning and characte ...
Helicobacter pylori, Helicobacter pylori SS1
Biochem. Biophys. Res. Commun.
319
1292-1298
2004
-
-
1
-
-
-
-
1
-
2
2
-
-
7
-
-
1
-
-
-
-
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1
1
1
1
-
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
2
2
-
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-
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1
-
-
-
-
1
1
1
1
-
1
1
1
-
-
-
-
-
-
-
-
656537
Zhou
Unique structural characterist ...
Leptospira interrogans
J. Mol. Biol.
339
207-215
2004
-
-
-
1
-
-
-
-
-
-
-
-
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4
-
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1
-
-
-
-
-
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-
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-
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-
-
-
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-
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671161
Kamo
Crystallization and preliminar ...
Thermus thermophilus
Acta Crystallogr. Sect. D
60
1299-1300
2004
-
-
1
1
-
-
-
-
-
1
-
1
-
4
-
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1
-
-
-
-
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1
-
-
-
-
-
-
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-
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1
-
1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672571
Molteni
Identification of novel potent ...
Staphylococcus aureus
Bioorg. Med. Chem. Lett.
14
1477-1481
2004
-
1
-
1
-
-
2
-
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1
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1
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4
-
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-
-
-
-
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1
-
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-
-
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1
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1
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-
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2
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1
-
1
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-
-
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-
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1
-
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-
-
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-
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672572
Cali
Isoxazole-3-hydroxamic acid de ...
Escherichia coli, Staphylococcus aureus
Bioorg. Med. Chem. Lett.
14
5997-6000
2004
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2
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6
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2
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2
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6
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2
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675061
Lee
Human mitochondrial peptide de ...
Homo sapiens
J. Clin. Invest.
114
1107-1116
2004
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-
-
-
-
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36
3
3
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1
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5
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19
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4
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1
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1
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33
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33
36
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3
3
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1
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19
-
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4
-
1
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1
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-
675277
Hu
Macrocyclic inhibitors for pep ...
Escherichia coli
J. Med. Chem.
47
4941-4949
2004
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1
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11
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1
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1
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3
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1
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1
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11
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1
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11
11
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1
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1
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1
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1
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1
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675278
Howard
A novel class of inhibitors of ...
Glycine max
J. Med. Chem.
47
6669-6672
2004
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1
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2
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1
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1
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1
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1
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1
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1
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-
675457
Sonke
-
Peptide deformylase as biocata ...
Escherichia coli
J. Mol. Catal. B
29
265-277
2004
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1
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1
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1
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15
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2
1
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1
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1
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15
-
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12
2
1
-
-
-
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-
676945
Tang
Increased peptide deformylase ...
Escherichia coli
Protein Expr. Purif.
36
100-105
2004
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1
1
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-
-
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1
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2
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1
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1
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-
-
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-
-
-
677000
Robien
An improved crystal form of Pl ...
Plasmodium falciparum
Protein Sci.
13
1155-1163
2004
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1
1
1
1
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1
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2
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1
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1
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1
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1
1
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1
1
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1
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1
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1
-
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-
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1
-
-
-
-
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-
-
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-
677037
Yoon
Crystal structure of peptide d ...
Staphylococcus aureus
Proteins
57
639-642
2004
-
1
1
1
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1
-
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1
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1
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2
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1
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1
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1
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1
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654445
Lee
A new human peptide deformylas ...
Homo sapiens
Biochem. Biophys. Res. Commun.
312
309-315
2003
-
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1
-
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1
2
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2
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3
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1
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1
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3
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2
1
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1
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1
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1
1
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2
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2
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1
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1
-
-
3
-
1
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2
1
-
-
-
-
-
-
-
-
-
654721
Nguyen
Characterization of a human pe ...
Escherichia coli, Homo sapiens
Biochemistry
42
9952-9958
2003
-
-
1
-
2
-
4
4
1
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-
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6
-
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1
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1
-
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10
-
-
-
-
4
-
-
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-
4
-
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1
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2
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4
4
4
1
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1
-
1
-
-
10
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
657299
Smith
Structural variation and inhib ...
Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae
Protein Sci.
12
349-360
2003
-
-
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4
-
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12
4
-
-
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9
-
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-
4
-
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-
-
4
-
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9
-
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4
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9
12
-
4
-
-
-
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-
-
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
666015
Kreusch
Structure analysis of peptide ...
Escherichia coli, Plasmodium falciparum, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus aureus ATCC 2913, Streptococcus pneumoniae, Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
J. Mol. Biol.
330
309-321
2003
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6
4
6
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17
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6
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15
6
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4
-
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6
-
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6
4
-
6
-
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17
-
6
-
6
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4
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393813
Li
Cloning, high-level expression ...
Leptospira interrogans
Acta Crystallogr. Sect. D
58
846-848
2002
-
-
1
1
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
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-
-
1
-
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-
-
-
-
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-
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1
-
1
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-
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1
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-
-
-
-
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1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
393814
Kumar
Crystals of peptide deformylas ...
Plasmodium falciparum
Structure
10
357-367
2002
-
1
1
1
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
1
1
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1
-
-
-
-
-
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-
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654057
Kim
Crystallization and preliminar ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
58
1874-1875
2002
-
-
1
1
-
-
1
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
1
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-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654059
Harris
Co-crystallization of Staphylo ...
Staphylococcus aureus
Acta Crystallogr. Sect. D
58
2153-2156
2002
-
-
-
1
-
-
-
-
-
-
-
-
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3
-
-
-
-
-
-
-
-
-
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-
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-
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-
1
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-
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-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654420
Li
Enzymatic properties of a new ...
Leptospira interrogans
Biochem. Biophys. Res. Commun.
295
884-889
2002
-
-
-
-
3
-
5
1
-
1
2
-
-
5
-
-
1
-
-
-
1
1
1
1
1
1
2
1
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
5
-
1
-
1
2
-
-
-
-
1
-
-
1
1
1
1
1
1
2
1
1
1
-
-
-
-
-
-
-
-
656069
Baldwin
Crystal structure of type II p ...
Staphylococcus aureus
J. Biol. Chem.
277
31163-31171
2002
-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666013
Guilloteau
The crystal structures of four ...
Escherichia coli, Geobacillus stearothermophilus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus aureus RN4220
J. Mol. Biol.
320
951-962
2002
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4
2
4
-
4
4
-
-
12
-
4
-
8
-
-
4
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
4
2
-
4
-
4
-
4
-
-
-
12
-
4
-
-
-
4
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393808
Grant
Inhibition and structure-activ ...
Escherichia coli
Bioorg. Chem.
29
211-222
2001
-
-
-
-
-
-
3
3
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
3
4
3
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393809
Serero
Distinctive features of the tw ...
Arabidopsis thaliana, Escherichia coli, Solanum lycopersicum
J. Mol. Biol.
314
695-708
2001
-
-
-
-
-
-
8
23
1
4
-
2
-
10
-
-
2
-
-
1
-
2
39
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
23
1
4
-
2
-
-
-
2
-
1
-
2
39
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
393810
Dirk
Eukaryotic peptide deformylase ...
Arabidopsis sp.
Plant Physiol.
127
97-107
2001
-
1
1
-
-
-
1
-
1
-
-
1
-
5
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393819
Haas
YkrB is the main peptide defor ...
Bacillus subtilis, Pseudomonas aeruginosa, Streptococcus pneumoniae, Streptococcus pyogenes
Microbiology
147
1783-1791
2001
-
1
1
-
-
-
1
2
-
-
-
-
-
8
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
656452
Apfel
2-(2-Oxo-1,4-dihydro-2H-quinaz ...
Escherichia coli
J. Med. Chem.
44
1847-1852
2001
-
-
-
-
-
-
16
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
16
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393798
Giglione
Peptide deformylase as a targe ...
Arabidopsis thaliana, Enterococcus faecalis, Escherichia coli, Geobacillus stearothermophilus, no activity in Caenorhabditis elegans, no activity in Saccharomyces cerevisiae, Plasmodium falciparum, Solanum lycopersicum, Staphylococcus aureus, Trypanosoma sp.
Mol. Microbiol.
36
1197-1205
2000
-
6
-
-
1
1
2
-
-
4
-
7
-
10
1
-
-
-
-
-
-
-
7
1
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
1
1
-
2
-
-
-
4
-
7
-
1
-
-
-
-
-
-
7
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393799
Green
Inhibition of bacterial peptid ...
Escherichia coli
Arch. Biochem. Biophys.
375
355-358
2000
-
-
1
-
1
1
4
1
-
1
-
1
-
4
1
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
2
-
4
-
-
1
-
-
1
1
4
4
2
1
-
1
-
1
-
1
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393800
Rajagopalan
Characterization of Cobalt(II) ...
Escherichia coli
Biochemistry
39
779-790
2000
-
-
1
-
4
1
2
8
-
2
-
-
-
2
1
-
1
-
-
-
-
1
5
-
-
-
-
5
1
2
1
-
-
-
-
-
-
1
-
-
4
1
-
2
-
8
-
2
-
-
-
1
-
1
-
-
-
1
5
-
-
-
-
5
1
2
1
-
-
-
-
-
-
-
393811
Apfel
Hydroxyamic acid derivates as ...
Escherichia coli
J. Med. Chem.
43
2324-2331
2000
-
1
-
-
-
-
2
-
-
-
-
-
-
7
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
393801
Hu
Determination of substrate spe ...
Escherichia coli
Biochemistry
38
643-650
1999
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
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-
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-
-
-
9
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
393812
Guo
A direct spectrophotometric as ...
Escherichia coli
Anal. Biochem.
273
298-304
1999
-
1
1
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
393817
Ragusa
Substrate recognition and sele ...
Escherichia coli
J. Mol. Biol.
289
1445-1457
1999
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13
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2
19
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2
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21
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19
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9
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13
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9
19
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21
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19
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393821
Durand
Peptide aldehyde inhibitors of ...
Bacillus subtilis, Escherichia coli
Arch. Biochem. Biophys.
367
297-302
1999
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6
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4
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5
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6
4
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4
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2
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393802
Becker
Iron center, substrate recogni ...
Escherichia coli
Nature Struct. Biol.
5
1053-1058
1998
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1
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3
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2
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3
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393803
Ragusa
Control of peptide deformylase ...
Escherichia coli, Geobacillus stearothermophilus, Thermus thermophilus
J. Mol. Biol.
280
515-523
1998
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1
2
7
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2
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6
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1
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1
1
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5
1
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7
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1
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2
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7
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2
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1
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1
1
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5
1
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7
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393804
Groche
Isolation and crystallization ...
Escherichia coli
Biochem. Biophys. Res. Commun.
246
342-346
1998
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1
1
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1
2
2
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3
1
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3
1
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1
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1
1
2
1
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1
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1
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1
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1
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2
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1
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1
1
2
1
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1
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393807
Rajagopalan
Oxygen-mediated inactivation o ...
Escherichia coli
J. Biol. Chem.
273
22305-22310
1998
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1
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1
1
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2
1
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2
2
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1
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1
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1
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1
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1
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1
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2
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1
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1
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1
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1
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393818
Becker
Structure of peptide deformyla ...
Escherichia coli
J. Biol. Chem.
273
11413-11416
1998
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1
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2
1
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2
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1
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3
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2
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1
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2
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393823
Evans
Truncation of peptide deformyl ...
Clostridium beijerinckii
Appl. Environ. Microbiol.
64
1780-1785
1998
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1
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7
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393805
Rajagopalan
Purification, characterization ...
Escherichia coli
Biochemistry
36
13910-13918
1997
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1
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1
11
1
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1
1
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4
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1
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1
8
1
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1
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1
1
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6
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2
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1
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1
2
11
6
1
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1
1
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1
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1
8
1
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1
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1
1
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393815
Rajagopalan
-
Peptide deformylase: A new typ ...
Escherichia coli, Haemophilus influenzae
J. Am. Chem. Soc.
119
12418-12419
1997
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1
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3
2
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2
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1
1
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1
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393816
Chan
Crystal structure of the Esche ...
Escherichia coli, Staphylococcus aureus
Biochemistry
36
13904-13909
1997
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1
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4
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393820
Mazel
A survey of polypeptide deform ...
Bacillus subtilis, Calothrix sp., Lactococcus lactis, Thermotoga maritima
J. Mol. Biol.
266
939-949
1997
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4
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12
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393822
Meinnel
A new subclass of the zinc met ...
Escherichia coli
J. Mol. Biol.
262
375-386
1996
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1
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1
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-
393806
Meinnel
Enzymatic properties of Escher ...
Escherichia coli
J. Bacteriol.
177
1883-1887
1995
1
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4
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1
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1
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1
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