Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the results of the study may provide the basis for the design of more potent and selective deformylase inhibitors as potential antibacterial agents | Escherichia coli | |
N-[4-(trifluoromethyl)benzoyl]-L-Met | time-dependent inhibition of zinc and cobalt deformylase, inhibition of full-length Co-PDF is competitive | Escherichia coli | |
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide | time-dependent inhibition of zinc and cobalt deformylase | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7.1 | - |
N-formyl-L-Met-L-Val | truncated cobalt deformylase | Escherichia coli | |
8 | - |
N-formyl-L-Met-L-Val | truncated zinc deformylase | Escherichia coli | |
12.4 | - |
N-formyl-L-Met-L-Val | full-length cobalt deformylase | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-formyl-L-methionine-polypeptide + H2O | Escherichia coli | posttranslational deformylation of N-formyl-Met-polypeptide | formate + L-methionine-polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
recombinant enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-formyl-L-Met-L-Val + H2O | - |
Escherichia coli | formate + L-Met-L-Val | - |
? | |
N-formyl-L-Met-Val + H2O | - |
Escherichia coli | formate + L-Met-Val | - |
? | |
N-formyl-L-methionine-polypeptide + H2O | posttranslational deformylation of N-formyl-Met-polypeptide | Escherichia coli | formate + L-methionine-polypeptide | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0116 | - |
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide | truncated Zn-PDF | Escherichia coli | |
0.0118 | - |
N-[4-(trifluoromethyl)benzoyl]-L-Met hydrazide | truncated Co-PDF | Escherichia coli | |
0.03 | - |
N-[4-(trifluoromethyl)benzoyl]-L-Met | - |
Escherichia coli | |
0.2 | - |
N-[4-(trifluoromethyl)benzoyl]-L-methionyl hydrazide | full-lenfth Co-PDF | Escherichia coli |