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Literature summary for 3.5.1.7 extracted from

  • Lieberman, I.; Kornberg, A.
    Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. III. ureidosuccinase (1955), J. Biol. Chem., 212, 909-920.
    View publication on PubMed
Search for more literature for 3.5.1.7

Activating Compound

Activating Compound Comment Organism Structure
cysteine
-
 Faecalicatena orotica
glutathione effect less than half that of cysteine Faecalicatena orotica
sulfhydryl compound
-
 Faecalicatena orotica

Inhibitors

Inhibitors Comment Organism Structure
Sodium thioglycolate
-
 Faecalicatena orotica

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
 Faecalicatena orotica
Fe2+
-
 Faecalicatena orotica
Mn2+ absolute requirement Faecalicatena orotica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ureidosuccinic acid + H2O Faecalicatena orotica only the L-isomer is attacked, the D form is completely inactive ?
-
 ?
additional information Faecalicatena orotica L-carboxymethylhydantoin is no substrate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Faecalicatena orotica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Faecalicatena orotica

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.4
-
-
 Faecalicatena orotica

Storage Stability

Storage Stability Organism
0°C stable for at least 10 days if kept in vacuo, loses activity rapidly when exposed to air either at 0°C or -16°C Faecalicatena orotica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoylglutamate + H2O small amount of activity found Faecalicatena orotica ?
-
 ?
L-carboxymethylhydantoin + H2O inert substrate Faecalicatena orotica CO2 + ?
-
 ?
L-ureidosuccinic acid + H2O only the L-isomer was attacked, the D form is completely inactive Faecalicatena orotica L-aspartic acid + CO2 + NH3
-
 ?
L-ureidosuccinic acid + H2O only the L-isomer is attacked, the D form is completely inactive Faecalicatena orotica ?
-
 ?
additional information L-carboxymethylhydantoin is no substrate Faecalicatena orotica ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8.5
-
 Faecalicatena orotica

pH Range

pH Minimum pH Maximum Comment Organism
5.1 9.6
-
 Faecalicatena orotica